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Pediatrics > Oncology > Flashcards

Oncology Flashcards

1
Q

Most common leukemia in childhood, peak at 2-6 y/o, M>F

A

ALL

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2
Q

Diagnostic test for ALL

A

Bone marrow aspiration

>25% of BM as homogenous pop of lymphoblast

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3
Q

Pathophysiology of ALL

A

Leukemic expansion and crowding out of the normal marrow

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4
Q

DDX of ALL

A

infectious mononucleosis
JRA
Aplastic anemia
ITP

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5
Q

Single most impt prognostic factor for ALL

A

treatment

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6
Q

3 most impt predictive factor of ALL

A

Age of the patient at the time of dx
Initial leukocyte count
Speed to tx response

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7
Q

Remission in ALL in lab result

A
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8
Q

Complication of ALL tx

A

Tumor lysis syndrome

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9
Q

Main chemotherapeutic agent in remission induction in ALL tx

A

Aspariginase for 4 weeks

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10
Q

Consolidation phase in ALL tx lasts for…

A

14-28 weeks

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11
Q

Maintenance phase for ALL

A

Mercaptopurine daily or methotrexate weekly for 2-3 yrs

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12
Q

Sites of relapse in ALL

A

Bone marrow, CNS, testes

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13
Q

Neoplasms of lymphoid cells

A

Lymphoma

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14
Q

Staging for lymphoma

A

Ann-Arbor Staging

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15
Q

Difference in PE finding of Hodgkin vs Nonhodgkin

A

Hodgkin: regional adenopathy
Nonhodgkin: systemic adenopathy

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16
Q

Virus associated with Burkitts lymphoma

A

EBV

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17
Q

Histo for Hodgkin’s

A

Reed Sternberg cells

18
Q

Most common NHL, 40%, Typical pic: African boy with unilat facial swelling

A

Burkitt lymphoma

19
Q

2/3 of brain tumors are located…

A

infratentorial (cerebellum mostly)

20
Q

Most common posterior fossa tumor, best prognosis

pic: 5-10 y, personality changes, with motor weakness, ataxia and seizures

A

Cerebellar astrocytoma

21
Q

Belongs to PNET, 2nd most common, originates at roof of 4th ventricle
pic:

A

Medulloblastoma

22
Q

3rd most common, infiltrates pons and brainstem

S/sx: personality changes, cranial nerve and long tract signs

A

Brain stem glioma

23
Q

Tumors occuring at 1st yr of life, with focal d/o

A

Supratentorial tumor

24
Q

Supratentorial tumor that has peripheral visual loss and sx of panhypopituitarism

A

Craniopharyngioma

25
Q

Renal tumor of embryonal origin, 2nd most common malignant abdominal tumor in childhood, 2-5 y/o

A

Wilms tumor

26
Q

Symptom of wilms tumor

A

Painless abdominal flank mass that does not cross the midline

27
Q

Predictors of bad prognosis on wilms tumor

A

large tumor
St 3 and 4
anaplastic histo

28
Q

Embryonal tumor if neural crest cell origin, 3rd most common pedia cancer

A

Neuroblastoma

29
Q

Sx of neuroblastoma

A

Nontender abdominal mass which may cross the midline

30
Q

Dx test for neuroblastoma

A

Abdominal CT scan
24-hr urine VMA and HVA
BUN, Crea, Bone scan, LFTs, CBC

31
Q

Stage of neuroblastoma with good prognosis, occurs in

A

Stage 4s

32
Q

Tumor of striated muscle, most common soft tissue sarcoma in children, occurs mainly on head and neck

A

Rhabdomyosarcoma

33
Q

3 diseases that causes blueberry muffin lesion

A

Congenital rubella
Congenital CMV infx
Disseminated neuroblastoma

34
Q

Highest risk for osteosarcoma to develop is…

A

adolescent growth spurt

35
Q

Sx of osteosarcoma

A

Deep bone pain causing nighttime awakening

36
Q

Classic xray finding of osteosarcoma

A

Sunburst pattern

37
Q

Cure for osteosarcoma

A

Complete surgical resection

38
Q

Site of predilection of osteosarcoma

A

metaphysis of long bone

39
Q

Site of predilection of Ewing sarcoma

A

Diaphysis of long bone

40
Q

Classic xray finding of Ewing sarcoma

A

Onion-skinning

41
Q

Primary tumor arising in the chest wall in ewing sarcoma

A

Askin tumor

42
Q

Most common malignant neoplasm in childhood

A

leukemia

Pediatrics (10 decks)

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