Oncology Flashcards
Features of High Risk ALL
- age < 1 or > 10
- WBC > 50 initially
- cytogenic abnormalities (Philadelphia chromosome)
- poor response to induction
- CNS and testicular disease
Electrolyte abnormalities in tumour lysis syndrome
- hyperkalemia
- hyperphosphatemia
- hypocalcemia
- hyperuricemia
- hyponatremia
- metabolic acidosis
Genetic Syndromes associated with childhood leukemia
- NF1
- T21
- Fanconi anemia
- Bloom syndrome
- Diamond Blackfan
- Shwachman Diamond
- Kostmann
- Ataxia-telangiectasia
- SCID
- Li-Fraumeni
Syndromes Associated with Wilm’s Tumour
- 11p-
- WAGR (aniridia)
- Denys-Drash
- NF1
- BWS
- Sotos
- Simpson-Golabi-Behmel
- Perlman
Syndromes associated with hepatoblastoma
- BWS
- VLBW/prem
- Glycogen storage disease
- Familial adenomatous polyposis
- T18
Surveillance for WT
- renal US q3months from birth - 8 years
Syndromes associated with neuroblastoma
- BWS
- CCHS (PHOX2B)
- Costello
- Noonan
- ROHHAD
Effects of Asparaginase
Acute
- anaphylaxis
- coagulopathy/clots
- hyperglycemia
- pancreatitis
Effects of Cisplatin
Acute
- +++nausea
- metallic taste
- tinnitus
- hypoMg
- renal dysfunction
Late
- SNHL (reversible)*
- nephrotoxicity*
Chemo Toxicities
Effects of Cyclophosphamide
Acute
- alopecia
- nausea
- hemorrhagic cystitis*
- SIADH
Late
- Infertility
- 2nd malignancies (leukemia > 5 years out), bladder)
Effects of Cytarabine
Acute
- Nausea
- Fevers
- Rashes
- Conjunctivitis
Effects of Doxorubicin
Acute
- nausea
- mucositis
- red secretions
- acute arrhythmia, heart failure
Late
- Heart failure (increases every year after administration - lifelong f/u)*
Effects of Etoposide
Acute
- Alopecia
- acute hypotension
- anaphylaxis
Late
- 2nd malignancy (Leukemia < 3 years out)
Effects of MTX
Acute
- mucositis*
- photosensitivity
- transaminitis
- leukoencephalopathy
Late
- learning/attention difficulties