Hematology Flashcards
Mentzer Index
MCV/RBC
< 13 = thalassemia
> 13 = IDA
How should infants of Rh -ve mothers be monitored?
If RhD antibody titer >/= 1:16 –> monitor fetal anemia with doppler US of middle cerebral artery (increased velocity of blood flow correlates with severity of anemia) and percutaneous umbilical cord sampling if indicated (if doppler suggestive of moderate to severe anemia)
Heinz Bodies
G6PD - oxidative stress
Pencil cells
IDA
CBC features of HS
MCHC >35.4 g/dL combined with a red cell distribution width (RDW) <14% has been suggested as a screening test for HS.
Hemolytic anemia!
Normal or slightly low MCV
Testing for HS
- osmotic fragility
- EMA fluorescence test
- Genetics (AD)
Hemoglobinopathy newborn screen
Testing for bleeding disorders
Hemophilia = prolonged PTT (mixing normal unless inhibitor present)
Interpretation of a Mixing Study
- corrects = factor deficiency
- does not correct/partial = inhibitor to a factor
- not corrected and no bleeding = lupus anticoagulant
Severity classification of Hemophilia
<1% = severe
1-5% = moderate
>5% = mild
Indications for DDAVP in bleeding disorders
- responder in VWD Type 1
- Hemophilia A (VIII) if mild
ECG findings in PE
Lab findings in DIC
- low fibrinogen
- low platelets
- low Factor II, III, V
- elevated PTT
- elevated INR
- elevated TT
- schistocytes on smear
Vaccines in hyposplenism
Indications for lymph node biopsy
Biopsy should be considered for the following reasons:
- suspicion of malignancy
- if the patient does not have resolution of lymphadenopathy over 4 to 6 weeks
- lymphadenopathy that steadily increases in size over 2 to 3 weeks
- lymphadenopathy greater than 2.0 cm
- multiple lymph nodes that have concerning features on ultrasonography or CT.
Low risk criteria for SCD and Fever
Acute Management of SCD Complications
