Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Fall 2021: Therapeutics III > Oncologic Immunotherapies (Wendt) > Flashcards

Oncologic Immunotherapies (Wendt) Flashcards

1
Q

List two HER2-targeting antibodies.

A

trastuzumab (Herceptin) and pertuzumab (Perjeta)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What antibody is known to bind HER2 and inhibit dimerization/oligomerization?

A

pertuzumab (Perjeta)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What could be considered a limitation to pertuzumab use?

A

it cannot be used in patients who have already received prior anti-HER2 therapy or chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drug was involved in the CLEOPATRA trial?

A

pertuzumab (Perjeta)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What two drugs should pertuzumab be co-administered with?

A

trastuzumab and docetaxel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

List some toxicities associated with trastuzumab.

A
  • flu-like symptoms
  • cardiomyopathy/CHF
  • hypersensitivity reactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

List two EGFR-targeting antibodies.

A

cetuximab (Erbitux) and panitumumab (Vectibix)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is cetuximab indicated for?

A

colorectal, head and neck cancers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What toxicities are associated with cetuximab?

A
  • severe infusion reaction (usually first dose)
  • acneiform rash (positive)
  • asthenias
  • fever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is panitumuab indicated for?

A

colorectal cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How often is panitumumab administered?

A

every 2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What side effects are associated with panitumumab?

A
  • skin rash
  • diarrhea

*no infusion toxicities!!!!!*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which antibody targets CD20?

A

ofatumumab (Kesimpta)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is ofatumumab indicated for?

A

B-cell non-Hodgkin’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which antibody targets VEGF?

A

bevacizumab (Avastin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is bevacizumab indicated for?

A

metastatic colorectal cancer (+5-FU)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Bevacizumab inhibits solid tumor growth via what effect?

A

anti-angiogenic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

List two ADCs.

A
  • ado-trastuzumab-emtansine (Kadcyla)
  • brentuximab vedotin (Adcetris)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is ado-trastuzumab emtansine indicated for?

A

HER2+ metastatic breast cancer (2nd line)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What toxicities are associated with ado-trastuzumab emtansine?

A
  • normal trastuzumab ones
  • thrombocytopenia
  • hepatotoxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Brentuximab vedotin is an anti-CD30 antibody conjugated to what?

A

MMAE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is brentuximab vedotin indicated for?

A

Hodgkin’s and certain T-cell lymphomas

23
Q

Reed-Sternberg cells express _______.

A

CD-30

24
Q

What drug is an IL-2 analog?

A

aldesleukin (Proleukin)

25
Q

What is aldesleukin indicated for?

A

a lot of shit; very nonspecific

26
Q

What toxicities are associated with aldesleukin?

A
  • fever
  • malaise
  • fatigue
  • anorexia
27
Q

Aldesleukin is highly _____________.

A

pro-inflammatory

28
Q

What antibody targets CTLA-4?

A

ipilimumab (Yervoy)

29
Q

What is ipilimumab indicated for?

A

advanced metastatic melanoma

30
Q

What adverse events are associated with Yervoy?

A

immune-mediated related to inflammatory response (enterocolitis, hepatitis, dermatitis, neuropathy, endocrinopathy)

31
Q

What antibody may require high-dose corticosteroids for adverse reactions?

A

ipilimumab

32
Q

List three PD-1-targeting antibodies.

A
  • pembrolizumab (Keytruda)
  • nivolumab (Opdivo)
  • cemiplimab (Litayo)
33
Q

Where is PD-1 expressed?

A

T-cells

34
Q

What are PD-1 inhibitors indicated for?

A
  • advanced metastatic melanoma following treatment with ipilimumab and a BRAF inhibitor (if BRAF-V600+)
  • NSCLC if PD-L1+
35
Q

List three PD-L1-targeting antibodies.

A
  • atezolizumab (Tecentriq)
  • avelumab (Bavencio)
  • durvalumab (Infinzi)
36
Q

Where is PD-L1 expressed?

A

tumor cells and macrophages

37
Q

What are PD-L1 antibody drugs indicated for?

A

NSCLC in patients with EGFR/ALK mutations that have progressed on those therapies

38
Q

What exclusions are there for PD-L1 drug use?

A
  • autoimmune disease
  • medical conditions requiring immunosuppression
39
Q

What drug is a bispecific antibody?

A

blinatumomab (Blincyto)

40
Q

What does blinatumomab bind?

A

CD19 and CD3

41
Q

What is blinatumomab indicated for?

A

B-cell lymphomas

42
Q

Is Blincyto a chimeric antibody?

A

hell nah

43
Q

With the exception of Provenge, what suffix indicates that a drug is CAR-T?

A

-leucel

44
Q

What is isolated from patients in CAR-T therapy?

A

T-cells

45
Q

What is CAR-T therapy indicated for?

A

B-cell/non-Hodgkin’s that hasn’t responded to other therapies

46
Q

In CAR-T therapy, all _______ are eliminated, but ________ live on indefinitely.

A

immature B-cells; T-cells

47
Q

What is isolated from the patient when utilizing sipleucel-T?

A

monocytes

48
Q

What is Provenge indicated for?

A

minimally symptomatic hormone-refractory prostate cancer

49
Q

What are some side effects of Provenge?

A

mostly flu-like, increased risk of stroke

50
Q

What HPV types does Gardasil protect against?

A

6, 11, 16, 18

51
Q

What HPV types does Cervarix protect against?

A

16 and 18

52
Q

How are HPV vaccines administered?

A

3 doses over 6 months

53
Q

What are the major causative agents for cervical cancer?

A

HPV 16 and 18

Fall 2021: Therapeutics III (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions