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Fall 2021: Therapeutics III > JUST Weddle's Cancer Regimens (I am so tired SOS) > Flashcards

JUST Weddle's Cancer Regimens (I am so tired SOS) Flashcards

1
Q

HER2+ drug regimen for non-metastatic breast cancer (2 possibilities)

A
  • DOCEtaxel + CARboplatin + TRAStuzumab + PERtuzumab
  • PAClitaxel + TRAStuzumab
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2
Q

HER2- chemotherapy regimen for non-metastatic breast cancer (2 possibilities)

A
  • DOXorubicin + CYClophosphamide + PAClitaxel
  • DOCEtaxel + CYClophosphamide
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3
Q

Chemo regimen for stage III low-risk colon cancer

A

CapeOx 3 months

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4
Q

Chemo regimen for stage III high-risk colon cancer

A

FOLFOX 6 months

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5
Q

Chemotherapy regimens for metastatic colon cancer (3 possibilities)

A
  • FOLFOX +/- bevacizumab
  • CapeOx +/- bevacizumab
  • FOLFIRI +/- bevacizumab
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6
Q

Treatment options for localized prostate cancer (3 possibilities)

A
  • active surveillance
  • radiation
  • surgery
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7
Q

Treatment options for m0HSPC (2 possibilities)

A
  • observation
  • ADT (LHRH)
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8
Q

Treatment options for m0CRPC

A

ADT + enza/apa/darolutamide

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9
Q

Drug regimens for low-volume m1HSPC (four possibilities)

A
  • ADT
  • ADT + abiraterone + prednisone
  • ADT + enza/apalutamide
  • Sipuleucel T
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10
Q

Drug regimens for high-volume m1HSPC (4 possibilities)

A
  • ADT
  • ADT + abiraterone + prednisone
  • ADT + enza/apalutamide
  • ADT + docetaxel
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11
Q

Drug regimens for m1CRPC (there’s a ton of options ngl)

A

ADT continued, plus:

  • sipuleucel T
  • docetaxel
  • carbazitaxel
  • radium-223
  • mitoxantrone
  • abiraterone + prednisone
  • enzalutamide
  • genomic testing
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12
Q

Treatment regimen for limited SCLC

A

RT + cisplatin + etoposide

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13
Q

Treatment regimen for extensive SCLC

A

duvalumab/atezolizumab + carboplatin + etoposide

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14
Q

Drugs to be used if SCLC relapse < 6 months (3 possibilities)

A
  • PO/IV topotecan
  • lurbinectidin
  • clinical trial
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15
Q

Treatment regimen for NSCLC resectable + non-squamous

A

surgery + cisplatin + pemetrexed

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16
Q

Treatment regimen for NSCLC resectable + squamous (2 possibilities)

A
  • surgery + cisplatin + gemcitabine
  • surgery + cisplatin + docetaxel
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17
Q

Treatment regimen for NSCLC unresectable + non-squamous (4 possibilities)

A
  • carboplatin + pemetrexed + RT
  • cisplatin + pemetrexed + RT
  • carboplatin + paclitaxel + RT
  • cisplatin + etoposide + RT
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18
Q

Treatment regimen for NSCLC unresectable + squamous (2 possibilities)

A
  • paclitaxel + carboplatin + RT
    • etoposide + cisplatin + RT
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19
Q

Drug for NSCLC unresectable maintenance

A

durvalumab

20
Q

Metastatic NSCLC EGFR mutant

A

osimertinib

21
Q

Metastatic NSCLC ALK mutant

22
Q

Metastatic NSCLC ROS-1 mutant

A

crizotinib

23
Q

Metastatic NSCLC BRAF mutant

A

dabrafenib + trametinib

24
Q

Metastatic NSCLC NTRK mutant

A

larotrectinib

25
Q

Metastatic NSCLC RET mutant

A

selpercatinib

26
Q

Metastatic NSCLC MEK14 mutant (2 possibilities)

A
  • capmatinib
  • tepotinib
27
Q

Metastatic NSCLC KRAS G12C mutant

28
Q

Metastatic NSCLC + non-squamous + PD-L1 > 50%

A

cemiplimab

29
Q

Ideal 3-drug combo for metastatic NSCLC + squamous

A

pembrolizumab + carboplatin + paclitaxel

30
Q

Metastatic NSCLC + non-squamous

A

carboplatin + pemetrexed + pembrolizumab

31
Q

Drug regimen for stage III melanoma (3 possibilities)

A
  • nivolumab
  • pembrolizumab
  • dabrafenib/trametinib (if BRAF mutant)
32
Q

Metastatic PD-1 positive melanoma (2 possibilities)

A
  • nivolumab
  • pembrolizumab
33
Q

Metastatic BRAF-positive melanoma (3 possibilities)

A
  • dabrafenib + trametinib
  • vemurafenib + cobimetinib
  • encorafenib + binimetinib
34
Q

Chemotherapy regimen for MOST ovarian cancers

A

paclitaxel + carboplatin

35
Q

Chemotherapy regimen for stage IIIC ovarian cancer

A

IP cisplatin + paclitaxel

(also an IV dose of paclitaxel but who cares)

36
Q

Maintenance PARP drug for BRCA ovarian cancer

37
Q

Maintenance PARP drug for ovarian cancer regardless of BRCA status

38
Q

Regimen for stage IA/IB seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

A
  • surveillance
  • radiation
  • carboplatin
39
Q

Regimen for stage IIA/IIB seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

A
  • radiation with iliac lymph nodes
  • BEP x 3
  • EP x 4
40
Q

Regimen for stage IIC/III good-risk seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

A
  • BEP x 3
  • EP x 4
41
Q

Regimen for stage IIC/III intermediate- or poor-risk seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

A
  • BEP x 4
  • VIP x 4
42
Q

Regimen for stage IA/IB non-seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

A
  • surveillance
  • RPLND
  • BEP x 1
43
Q

Regimen for stage IIC/III good-risk non-seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

A
  • BEP x 3
  • EP x 4
44
Q

Regimen for stage IIA/IIB non-seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

A
  • RPLND
  • BEP x 3
  • EP x 4
45
Q

Regimen for stage IIC/III intermediate- or poor-risk non-seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

A
  • BEP x 4
  • VIP x 4
46
Q

What does BEP stand for?

A

bleomycin, cisplatin, etoposide

47
Q

What does VIP stand for?

A

etoposide, ifosfamide (+ mesna), cisplatin

Fall 2021: Therapeutics III (25 decks)

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