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Step 1 > Oncogenes/Tumor Supressors > Flashcards

Oncogenes/Tumor Supressors Flashcards

1
Q

abl

A

Oncogene
CML
Tyrosine Kinase

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2
Q

c-myc

A

Oncogene
Burkitt’s
Transcription Factor

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3
Q

bcl-2

A

Oncogene
Follicular and undifferentiated lymphomas
stabilizer of mitochondrial membrane (anti-apoptosis)

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4
Q

HER2/neu/c-erbB2

A

Oncogene
Breast, ovarian, gastric carcinoma
Tyrosine kinase

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5
Q

ras

A

Oncogene
colon carcinoma
GTPase, MAP pathway

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6
Q

L-myc

A

Oncogene
Lung tumor
transcription factor

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7
Q

N-myc

A

Oncogene
Neuroblastoma
transcription factor

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8
Q

ret

A

Oncogene
MEN 2A/2B
Tyrosine kinase

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9
Q

c-kit

A

Oncogene
GI stromal tumor (GIST)
Cytokine Receptor

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10
Q

Rb

A

tumor suppressor
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1 –> S
bound by E7 in HPV

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11
Q

p53

A

tumor suppressor
most cancers, Li-Fraumeni syndrome
Blocks G1-> S
Bound by E6 in HPV

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12
Q

BRCA1/2

A

tumor suppressor
Breast and ovarian Ca
DNA repair

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13
Q

p16

A

tumor suppressor

melanoma

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14
Q

BRAF

A

tumor suppressor

melanoma

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15
Q

APC

A

tumor suppressor – maintains CAMs and decr beta-catenin (oncogenic)
CRC (FAP)

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16
Q

WT1

A

tumor suppressor

Wilm’s tumor

17
Q

NF1

A

tumor suppressor
NF1
RAS GTPas activating protein

18
Q

NF2

A

tumor suppressor
NF2
Merlin (schwannomin) protein

19
Q

DPC4

A

tumor suppressor

Pancreatic cancer

20
Q

DCC

A

tumor suppressor

colon cancer

Step 1 (15 decks)

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