Oncogenes and tumor supressors Flashcards
1
Q
BCR ABL
A
CML and ALL
2
Q
Bcl2
A
follicular and undifferentiated lymphoma
3
Q
BRAF
A
Melanoma
4
Q
cKIT
A
GIST
5
Q
cMYC
A
Burkitt
6
Q
L myc
A
Lung
7
Q
Nmyc
A
neuroblastoma
8
Q
Ras
A
GTPase,
Colon, lung, pancreatic
9
Q
RET
A
Tyrosine kinase
MEN2A and 2B
10
Q
CPD4/SMAD4
A
pancreatic,
Gene product: deleted in pancreatic acancer
11
Q
DCC
A
Deleted in colon cancer
12
Q
MEN1
A
Men type 1
13
Q
NF1
A
NF1
RAS GTPase activing protein
Neurofibromin
14
Q
NF2
A
Merlin protein
Schwannomin
15
Q
p16
A
Melanoma,
cyclin dependent kinase inhibitor 2a
16
Q
p53
A
Li Fraumeni syndrome
Transcription factor for p21
blocks G1 to S
17
Q
PTEN
A
Breast cancer, prostate cancer, endometrial cancer
18
Q
Rb
A
Retinoblastoma, osteocarcoma
19
Q
TSC1/TSC2
A
Tuberous sclerosis
TSC1: Hamartin protein
TSC2: tuberin protein
20
Q
VHL
A
inhibit HIF1
