Carcinogens Flashcards
Alkylating agents
Blood
Leukemia and lymphoma
Aromatic amine
Bladder
Examples: bendizine, 2-naphthylamine
Transitional cell carcinoma
Arsenic
Liver = angiosarcoma Lung= lung cancer Skin= squamous cell carcinoma
Asbestos
Lung
Bronchogenic carcinoma> mesothelioma
CCl3
Liver Centriolobular necrosis (Zone III) fatty change
Cigarette
Bladder = transitional cell carcinoma Esophagus = SCC/adenocarcinoma Kidney = RCC Larynx = SCC and SCC Pancreas= pancreatic adenocarcinoma
Ethanol
Liver = HCC
Ionizing agents
Thyroid
Papillary thyroid carcinoma
Nitrosamines
Gastric cancer
Radon
Lung cancer,
2nd leading cause after cigarette
Vinyl chloride
Liver
Angiosarcoma
Paraneoplastic syndrome:
Hypercalcemia
Elevated calcitriol
Hodgkin and some non Hodgkins
Paraneoplastic syndrome:
Cushing
Small cell lung carcinoma
Paraneoplastic syndrome:
SIADH
Small cell lung carcinoma
Intracranial neoplasms
Paraneoplastic syndrome:
Lambert-Eaton myasthenic syndrome
Small cell lung carcinoma
Paraneoplastic syndrome:
Polycthemia
EPO
RCC, thymoma, hemangioblastoma, HCC, leiomyoma, pheo
Paraneoplastic syndrome:
Hypercalcemia
PTHrP
SCC of lung cancer,
RCC
Breast Ca
Psammoma bodidies
Papillary carcinoma of thyroid
Serous papillary cystadenoma of ovary
Meningioma
Malignant mesothelioma
Cancer epidemiology
Incidence:
Male: prostate > lung > colon/rectum
Female: breast> lung> colon/rectum
*lung cancer incidence dropped in men, but has not changed in women
Mortality Male: lung> prostate Female: lung> breast *cancer is the 2nd leading cause of death in the US, CV is the 1st.
