Complements and IL

Question 1

C1 esterase inhibitor defieincy

Answer 1

Hereditary angioedema

ACE contraindicated

Question 2

C3 deficiency

Answer 2

Severe, recurrent pyogenic sinus and URI.

Increased susceptibility to type III HS rxn

Question 3

C5-9 deficiencies

Answer 3

Recurrent Neisseria bacteremia

Question 4

DAF (GPI anchored enzyme) deficiency

Answer 4

Complement mediated lysis of RBC and PNH

Question 5

Macrophage ILs

Answer 5

IL1: pyrogen, fever, inflammation, endothelium to express adhesion molecules, induce chemokines

IL6: pyrogen (also by Th2), fever and production of acute phase protein

IL8: chemotatic factor for neutrophil

IL12: differentiation of T cells into TH1, activates NK (also secreted by B cells)

TNFa: septic shock, activates endothelium, recrutis leukocytes, vascular leak

Question 6

ILs secreted by all T cells

Answer 6

IL2: stimulate the growth of helper, cytotoxic, and regulatory T cells

IL3: supports the growth and differentitation of BM stem cell
“ IL3= GM-CSF”

Question 7

ILs secreted by TH1 cells

Answer 7

IFN gamma: activates MP and TH1 cells
Suppresses TH2 cells
Antiviral and antitumor activity

Question 8

ILs secreted by TH2 cells

Answer 8

IL4: induce differentiation to TH2, promotes growth of B cells, enhance class switching to IgE and IgG

IL5: promotes differentiation of B cells, enhance class switching to IgA. stimulates the growth and differentiation of eosinophils

IL6: pyrogen, fever, also secreted by MP

IL10: modulates inflamm response, inhibit activated T cells and TH1, also secreted by T reg.
“IL10=similar action as TGFb”

Question 9

IFN

Answer 9

• alpha and beta: anti viral
• gamma: induce MHC I and II expression and antigen presentation in all cells
• Activates NK cells to kill virus induced cells