Oncogenes and Associated Tumors Flashcards
PDGFB = platelet derived growth factor
Growth Factor
Astrocytoma
ERBB2 = epidermal growth factor receptor
HER2/neu
(Growth Factor Receptor)
Subset of breast carcinomas
RET = neural growth factor receptor
Growth Factor Receptor
MEN 2A
MEN 2B
Sporadic medullary carcinoma of thyroid
KIT = stem cell growth factor receptor
Growth Factor Receptor
Gastrointestinal Stromal Tumor
RAS gene family = GTP-binding protein
Signal Transducers
Carcinomas
Melanoma
Lymphoma
ABL = a tyrosine kinase
Signal Transducer
CML
Some types of ALL
(t[9;22] with BCR)
c-MYC
Nuclear Regulators
Burkitt lymphoma
t[8;14] involving IgH
N-MYC
Nuclear Regulators
Neuroblastoma
L-MYC
Nuclear Regulators
Small Cell Lung Carcinoma
CCND1
Cyclin D1
(Cell Cycle Regulators)
Mantle Cell Lymphoma
t[11;14] involving IgH
CDK4 = cyclin-dependent kinase
Cell Cycle Regulator
Melanoma