Oncogenes and Associated Tumors Flashcards

1
Q

PDGFB = platelet derived growth factor

Growth Factor

A

Astrocytoma

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2
Q

ERBB2 = epidermal growth factor receptor
HER2/neu
(Growth Factor Receptor)

A

Subset of breast carcinomas

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3
Q

RET = neural growth factor receptor

Growth Factor Receptor

A

MEN 2A
MEN 2B
Sporadic medullary carcinoma of thyroid

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4
Q

KIT = stem cell growth factor receptor

Growth Factor Receptor

A

Gastrointestinal Stromal Tumor

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5
Q

RAS gene family = GTP-binding protein

Signal Transducers

A

Carcinomas
Melanoma
Lymphoma

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6
Q

ABL = a tyrosine kinase

Signal Transducer

A

CML
Some types of ALL
(t[9;22] with BCR)

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7
Q

c-MYC

Nuclear Regulators

A

Burkitt lymphoma

t[8;14] involving IgH

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8
Q

N-MYC

Nuclear Regulators

A

Neuroblastoma

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9
Q

L-MYC

Nuclear Regulators

A

Small Cell Lung Carcinoma

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10
Q

CCND1
Cyclin D1
(Cell Cycle Regulators)

A

Mantle Cell Lymphoma

t[11;14] involving IgH

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11
Q

CDK4 = cyclin-dependent kinase

Cell Cycle Regulator

A

Melanoma

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