Oncogenes Flashcards
1
Q
What are the growth factor receptors?
A
- ERB-2 (her2/neu)
- Ret
- Kit
2
Q
What are the signal transducers?
A
- Ras
2. ABL
3
Q
What are the nuclear regulators?
A
- C-myc
- N-myc
- L-myc
4
Q
What are the cell cycle regulators?
A
- Cyclin D1
2. CDK4
5
Q
What are the tumor suppressor genes?
A
- p53
2. Rb
6
Q
What is the regulator of apoptosis?
A
Bcl2
7
Q
What is the f=growth factor?
A
PDGF
8
Q
PDGF
A
- overexpression seen in astrocytoma
9
Q
ERB2
A
- HER2/neu
- amplification of epidermal growth factor seen in breast cancer
10
Q
Ret
A
- growth factor
- point mutation seen in MEN 2A, 2B and sporadic medullary carcinoma of the thyroid
11
Q
Kit
A
- stem cell growth factor point mutation seen in GIST
12
Q
Ras
A
- GTP binding point mutation- GAP usually turns off Ras but this is mutated to turn it on
- seen in carcinomas, melanomas and lymphomas
13
Q
ABL
A
- tyrosine kinase translocation t9;22 with BCR
- CML and some ALL
14
Q
C-myc
A
- transcription factor regulator, t(8;14)
- Burkitt lymphoma
15
Q
Chromosome 14 has what?
A
the Ig heavy chain = always expressed
16
Q
N-myc
A
amplification of transcription factor
- seen in neuroblastoma
17
Q
L-myc
A
- amplification of transcription factor
- seen in small cell lung carcinoma
18
Q
Cyclin D1
A
- cell cycle regulator, translocation t11;14
- cyclin D allows G1 -> S
- Mantle cell lymphoma
19
Q
CDK4
A
amplification of cell cycle regulator
- seen in melanoma
