Immuno notes

Question 1

How to MHC class I and II cells differ in their presentation of antigen?

Answer 1

MHC class I: have heavy chain and beta 2 microglobulin, antigen are processed in the cytoplasm
MHC class II: alpha and beta polypeptide chains, antigens are phagocytosed and digested by lysosomes within which antigens bind to MHC class II

Question 2

only lymphocyte member of the innate immune system

Answer 2

natural killer cells

Question 3

what vitamin do granulomas secrete?

Answer 3

vitamin D

Question 4

recurrent bacterial infections and giardiasis

Answer 4

X linked brutons agammaglobulinemia

Question 5

disseminated mycobacterial infections

Answer 5

IL-12 receptor deficiency

Question 6

retained teeth, coarse facies, noninflamed staph abscesses

Answer 6

Hyper-IgE syndrome, Th1 fails to produce IFN-y

Question 7

recurrent candida infections

Answer 7

chronic mucocutaneous candidiasis: t cell dysfunction

Question 8

false positive BHCG tests due to presence of heterophile antibody

Answer 8

Selective IgA deficiency

Question 9

poor smooth pursuit with eyes and recurrent infections

Answer 9

ataxia telangiectasia

Question 10

CD18

Answer 10

LFA-1 integrin, seen in leukocyte adhesion deficiency

Question 11

What is BTK?

Answer 11

found defective in brutons agammaglobulinemia = tyrosine kinase