OME - Day 9 Flashcards
Macrocytic anemia, what is the next step?
Blood smear (not B12 and Folate)
Megaloblastic anemia, differential?
B12 deficiency and Folate deficiency.
Normocytic anemia, decreased reticulocyte count, differential?
Cancer and CKD
Normocytic anemia, elevated reticulocyte count, differential?
Hemorrhage and Hemolysis
Pallor, tachycardia, dyspnea on exertion, diagnosis?
Anemia
Two tests you should look at with every anemia
MCV and Retic Count
What are 4 causes of Microcytic anemia?
Iron Deficiency, Anemia of Chronic Inflammatory Disease, Thalassemia, and Sideroblastic
Diagnose Pernicious anemia, what’s the best test?
EGD with biopsy showing atrophy of gastric mucosa
Diagnose Pernicious anemia, what’s the first step?
Anti-IF and Anti-parietal cell antibodies
Tea and toast diet, diagnosis?
Folate deficiency
What leads to a non-megaloblastic anemia?
Lead, Toxins, Cirrhosis
What separates B12 from folate deficiency?
Neurologic symptoms (irreversible)
What test can you get if the B12 and Folate are equivocal?
Methylmalonic Acid (B12 def elevated, Folate def not elevated)
A picture of a red blood cell with a circle of darkly pigmented iron, what’s the diagnosis?
Sideroblastic anemia (ringed sideroblasts)
Decreased Ferritin, increased TIBC, decreased iron, diagnosis?
Iron deficiency anemia
Elevated ferritin, decreased TIBC, decreased iron, diagnosis?
Anemia of chronic inflammatory disease
How do you diagnose thalassemia?
Hemoglobin electrophoresis