OME - Day 10 Flashcards
80 year old man with fatigue, lymphadenopathy, splenomegaly, and with a white count of 80,000 (99% lymphocytes), diagnosis?
CLL
Auer Rods, diagnosis and next step?
AML, M3, treat with all-trans retinoic acid
Blast Crisis?
CML conversion into AML
CALLA and TdT positive?
ALL
Child, bone pain, frequent infection, diagnosis?
ALL
How do you treat CML?
Imatinib
T(9,22)?
Philadelphia Chromosome, BCR-ABL, CML
What does the bone marrow look like in acute leukemia?
> 20% blasts
What is the treatment of ALL?
ARA-C intrathecally
Fever that come and go, cyclical fevers, diagnosis?
Pel-Epstein fever = Hodgkin’s
How do you determine the stage of Lymphoma?
CT scan chest / abdomen
How do you treat early stage lymphoma?
Radiation
How do you treat late stage lymphoma?
Chemo
Nontender lymphadenopathy made worse with alcohol, diagnosis?
Hodgkin’s Lymphoma
Nontender Lymphadenopathy?
Excisional biopsy (not FNA)
Picture of Reed-Sternberg Cells shows what?
Hodgkin’s Lymphoma
Starry Sky pattern on biopsy shows what?
Burkitt’s Non-Hodgkin’s Lymphoma
What are B symptoms?
Fever, weight loss, night sweats
What are side effects of Bleomycin?
Pulmonary Fibrosis
What are side effects of Cisplatin?
Ototoxicity, Nephrotoxicity
What are side effects of Daunorubicin?
Dose dependent, irreversible, CHF
What are side effects of Vincristine?
Peripheral Neuropathy
< 10% Plasmacytosis in the marrow, but Multiple myeloma?
MGUS
70 year old man with hypercalcemia, renal failure, anemia, and bone pain, diagnosis?
Multiple Myeloma (CRAB)
Bone marrow biopsy on Waldenstrom’s?
> 10% Lymphocytosis
Monoclonal expansion of IgG, diagnosis?
Multiple Myeloma
Monoclonal expansion of IgM, diagnosis?
Waldenstrom’s
Pattern of testing in Multiple Myeloma?
SPEP + , UPEP +, Skeletal Survey +, Bone Marrow Biopsy > 10% plasmacytes
SPEP positive, but nothing else in myeloma workup?
MGUS
What are the symptoms of Waldenstrom’s?
Hyperviscosity syndrome
What is the first Step in Multiple Myeloma?
Serum and Urine Electrophoresis (called Immunofixation)
How do you treat recurrent venous thrombosis?
Life long anticoagulation
How does the presence of an inherited thrombophilia alter your management?
It doesn’t
Most common inherited thrombophilia?
Factor V Leiden
Which can you not test for during an acute clot?
Protein C, Protein S, and Antithrombin 20210 A
Which can you test for during an acute clot (but you wont)?
Those that are mutations: Factor V Leiden, Prothrombin
