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Step 3 > OME - Day 10 > Flashcards

OME - Day 10 Flashcards

1
Q

80 year old man with fatigue, lymphadenopathy, splenomegaly, and with a white count of 80,000 (99% lymphocytes), diagnosis?

A

CLL

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2
Q

Auer Rods, diagnosis and next step?

A

AML, M3, treat with all-trans retinoic acid

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3
Q

Blast Crisis?

A

CML conversion into AML

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4
Q

CALLA and TdT positive?

A

ALL

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5
Q

Child, bone pain, frequent infection, diagnosis?

A

ALL

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6
Q

How do you treat CML?

A

Imatinib

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7
Q

T(9,22)?

A

Philadelphia Chromosome, BCR-ABL, CML

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8
Q

What does the bone marrow look like in acute leukemia?

A

> 20% blasts

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9
Q

What is the treatment of ALL?

A

ARA-C intrathecally

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10
Q

Fever that come and go, cyclical fevers, diagnosis?

A

Pel-Epstein fever = Hodgkin’s

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11
Q

How do you determine the stage of Lymphoma?

A

CT scan chest / abdomen

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12
Q

How do you treat early stage lymphoma?

A

Radiation

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13
Q

How do you treat late stage lymphoma?

A

Chemo

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14
Q

Nontender lymphadenopathy made worse with alcohol, diagnosis?

A

Hodgkin’s Lymphoma

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15
Q

Nontender Lymphadenopathy?

A

Excisional biopsy (not FNA)

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16
Q

Picture of Reed-Sternberg Cells shows what?

A

Hodgkin’s Lymphoma

17
Q

Starry Sky pattern on biopsy shows what?

A

Burkitt’s Non-Hodgkin’s Lymphoma

18
Q

What are B symptoms?

A

Fever, weight loss, night sweats

19
Q

What are side effects of Bleomycin?

A

Pulmonary Fibrosis

20
Q

What are side effects of Cisplatin?

A

Ototoxicity, Nephrotoxicity

21
Q

What are side effects of Daunorubicin?

A

Dose dependent, irreversible, CHF

22
Q

What are side effects of Vincristine?

A

Peripheral Neuropathy

23
Q

< 10% Plasmacytosis in the marrow, but Multiple myeloma?

A

MGUS

24
Q

70 year old man with hypercalcemia, renal failure, anemia, and bone pain, diagnosis?

A

Multiple Myeloma (CRAB)

25
Q

Bone marrow biopsy on Waldenstrom’s?

A

> 10% Lymphocytosis

26
Q

Monoclonal expansion of IgG, diagnosis?

A

Multiple Myeloma

27
Q

Monoclonal expansion of IgM, diagnosis?

A

Waldenstrom’s

28
Q

Pattern of testing in Multiple Myeloma?

A

SPEP + , UPEP +, Skeletal Survey +, Bone Marrow Biopsy > 10% plasmacytes

29
Q

SPEP positive, but nothing else in myeloma workup?

A

MGUS

30
Q

What are the symptoms of Waldenstrom’s?

A

Hyperviscosity syndrome

31
Q

What is the first Step in Multiple Myeloma?

A

Serum and Urine Electrophoresis (called Immunofixation)

32
Q

How do you treat recurrent venous thrombosis?

A

Life long anticoagulation

33
Q

How does the presence of an inherited thrombophilia alter your management?

A

It doesn’t

34
Q

Most common inherited thrombophilia?

A

Factor V Leiden

35
Q

Which can you not test for during an acute clot?

A

Protein C, Protein S, and Antithrombin 20210 A

36
Q

Which can you test for during an acute clot (but you wont)?

A

Those that are mutations: Factor V Leiden, Prothrombin

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