OM E1 Flashcards
Which type of immunity is quick to respond, will attack a broad range of invaders and has no memory?
Innate
What type of immunity is slow to respond, has high specificity and has a memory?
Adaptive
What is optimization?
The process of coating an antigen with antibodies to enhance phagocytosis. (puts sand on the slippery soap)
What is immunogenic?
Induces an adaptive immune response
What 3 organisms cause Meningitis in children under 2 years of age?
Strep. pneumonia
Nesseria Meningitus
Haemophilus Influenza
Name 6 “Defense Molecules”?
- Immunoglobulin (Antibodies)
- Histocompatability Ag.
- T-cell receptor
- Cytokines
- Fc Receptors
- Cytokine Receptors
Name 3 types of Exotoxins.
Super Antigen
Cytolytic
A-B Toxin
What causes Hypersensitivity reactions?
When the Adaptive Immunity over-responds to infection, consequently causes damage to the body
What are the Domains of Life?
Prokaryote- Bacteria and Archaea
Eukaryote
What is a pathogen?
Organisms with unique capacity to colonize a host, overcome host immunity, replicate w/in host environment and/or cause damage to host tissue
Name the 5 major infectious agents.
- Bacteria
- Archaea
- Viruses
- Prions
- Eukaryotes (Hemalinths, Protozoa, Fungi)
Name the major characteristics unique to Bacteria.
- No inner organelles
- 70s Ribosomes
- Complex cell walls (Gram + thick, Gram - thin CW w/in 2 membranes, outer has LPS)
- 1000 X smaller than human cells
- Secrete enzymes to digest host sugar, proteins and Fe++
What are some of the components of the Innate processes of Oral Immunity?
- Saliva- H2O flush, dissolve food, buffers acids, Ab molecules, protective coating
- Thick, continually recycling epithelium- though keratin layer w/ high lipid count, tight jct. and impermeable
- Gingival jct. ep –> leaky Non-ker low lipid content, loose jct., allows plasma and inf. cells into mouth
- Competitive normal flora
How does saliva protect agains micro organisms?
- Contains IgA
- Non-specific anti-microbial agents, such as LYSOZYME
- Dilutes and washes away Toxins and Acids prod. by microbes
What is in Crevicular fluid?
- Ab., Hemin, Complement (Low in saliva)
2. Cells: 90% PMNs, 10% Macrophages and Lymphocytes (HIGH IgG, low IgA)
What are the defensive features of Saliva?
- HIGH IgA, low IgG
- Non-specific antimicrobial (Lysozyme, lactoferrin, peptides)
- Buffers pH from acid produced by microbes
- Dissolves/dislodges food particles
What are some of the attributes of sIgA?
- Sticks to mucins on epithelium
- Resistance to proteases
- Can neutralize viruses/toxins
- Blocks colonization of microbes