Oesophageal Disease Flashcards
There are four major areas that oesophgeal disease can fall into, what are they?
Anatomic
Obstruction
Oesophagitis
Motility Disorders
What can symptoms of oesophageal disorders be?
hypersalivation odynophagia anorexia dysphagia coughing nasal dishcharge
What differentiates vomiting and regurgitation?
Vomiting has abdominal effort and a nausea associated. It is usually digested food. Regurgitation is a passive event and is usually undigested food.
What is a common complication of regurgitation?
Aspiration pneumonia
Which antibiotic can cause oesophagitis commonly?
Doxycycline
Where are 3 common sites for oesophageal foreign bodies to lodge?
heart base, thoracic inlet and the hiatus.
What is the mechanism of sucralfate?
reacts with HCL and is polymerised to form a sticky substance that makes a protective cover over ulcer sites.
What is the mechanism of cimetidine/rantidine/famotidine?`
H2 receptor anagonist that inhibits secretion of gastric acid and had prokinetic (gastric) effects.
What is the mechanism of action of omeprazole?
protein pump inhibitor - long duration of action
What is the mechanism of action of metaclopramide?
paraaminobenzoic acid derivative. antagonises D2 and 5-HT3 receptors in the chemoreceptor trigger zone has an upper GI prokinetic effect
What is the mechanism of action of Ondansatron?
5-HT3 seratogenic antagonist
expensive
best for chemotherapy induced nausea and good for pancreatitis.
What is the pathway involved in the regulation of acid secretion?
see diagram
What is the mechanism of Maroptiant?
neurokinin 1 receptor antagonist and has central and peripheral effects
you can mask underlying diseases as very potent drug.
