Odontogenic cysts - keratocyst

Question 1

Keratocysts common or uncommon?

Answer 1

uncommon

Question 2

Are keratocysts aggressive?

Answer 2

aggressive cysts

Question 3

Do keratocysts recur?

Answer 3

yes

keeps getting changed from a tumour to a cyst… WHO keep changed definition

Question 4

karatocysts unusual or normal growth pattern?

Answer 4

unusual

Question 5

Age range of keratocyst?

Answer 5

wide age range or people

peak during 20s and 30s

peak during 50s and 60s

Question 6

Why do keratocys have 2 age peaks where they are detected?

Answer 6

as they can go undetected for so long

Question 7

keratocyst more common in males of females?

Answer 7

males

Question 8

What teeth are usually affected by ketatocyst?

Answer 8

posterior to first premolar

Question 9

Do most cases affect the maxilla or mandible?

Answer 9

mandible

posterior ascending ramus

Question 10

Do keratocysts appear as single or multiple lesions?

Answer 10

single lesions

Question 11

Are keratocysts symptomatic?

Answer 11

few symptoms

Question 12

When do ketatocysts cause pain?

Answer 12

pain if superimpsed by inflammation

Question 13

What way do keratocysts expand?

Answer 13

anterior-posterior direction

Question 14

Do keratocysts case bone resorption?

Answer 14

large sizes without any bony resorption

Question 15

Do keratocysts affet teeth roots?

Answer 15

yes

root resorption

Question 16

well defined or undefined radiolucencies?

Answer 16

well defined

Question 17

unilocular or multilocular?

Answer 17

can be both

mostly multilocular

Question 18

keratocysts can be associated with unerupted teeth, how do keratocysts differ from dentigerous cysts?

Answer 18

keratocysts is separated form the crown - shown in image

dentigerous cysts are attached to crown

Question 19

describe this cyst?

Answer 19

multilocular

well defined

radiolucent

extend from mandible to ramus

Question 20

does the keratocyst have a thin or thin lining?

Answer 20

thin lining (5-10 cells thick)

Question 21

Describe the walls of the keratocyst?

Answer 21

thin lining

folded wall

well defined basal layer

abrupt change form prickle cell layer to keratin formation

parakeratin stratified squamous epithelium

mitotic figures in basal and parabasal layers

Question 22

keratocyst lining para or ortho keratin?

Answer 22

parakeratin

Question 23

What is found in the basal and parabasl layers?

Answer 23

mitotic figures

Question 24

What do mitotic cell indicate?

Answer 24

active proliferation

contributes to growth and recurrence if some of lining is left

Question 25

EXAM: What features make keratocysts reccur aggressive?

Answer 25

thin fragile lining

folded walls

mitotic figures - tend to proliferate

daughter cysts within capsule

satellite cells (satellite cysts)

epithelial rests within capsule

Question 26

When inflamed what do keratocysts resemble?

Answer 26

radicular cysts

Question 27

Contents of the keratocyst?

Answer 27

thick

grey white material

keratinous debris

little free fluid

Question 28

Why do the odontogenic keratocysts grow?

Answer 28

not due to osmosis but active proliferation

• active epithelial growth with high mitotic activity

–> proliferation occurs in clusters

• cellular activity in capsule
• production of bone resorbing factors

Question 29

Why do the keratocyst go undetected for decades?

Answer 29

anterior - posterior expansion

Question 30

Does intracystsic pressure contribute to cyst growth?

Answer 30

no

Question 31

What syndrome can be predispose to having keratocysts?

Answer 31

Gorlin syndrome

Question 32

Gorlin syndrome also called?

Answer 32

naevoid basal cell carcinoma syndrome

Question 33

genetics of Gorlin syndrome?

Answer 33

multiple cysts

autosomal dominant

mutation to a tumour suppressor gene chromosome 9q

Question 34

features of Gorlin syndrome?

Answer 34

skin lesions due to carcinoma

Question 35

What is shown here?

Answer 35

Gorlin syndrome