odontogenesis part 2 Flashcards
during initiation- what factors are being released from the epithelium to the mesenchyme?
fgf8, shh, bmp4
during initiation, what factors are produced in the mesenchyme in response to epithelial factors?
ms1x
pax9 is blocked
what is pax 9 important in?
tooth positioning
in tooth bud stage, what factors are released from the mesenchyme to the epithelium?
pax9
msx1
bmp
in tooth bud stage, what factors are formed in the epithelium?
msx2
lef1
p21
bmp
in the cap stage what factors are produced?
p21 and msx2 cause proliferation out towards sides of bud (enamel knot signalling) and down into the mesenchymal tissue
what gf’s produce each teeth?
anterior-canine- msx1 and msx2
pre molar- dlx
molar- barx
why is the extracellular matrix important in tooth development?
allows for
morphogenesis
differentiation
adhesion
proliferation
polarisation
to occur- as they bind receptors that are needed to bind to things like gf’s for these processes to happen
what do the ecm express ?
collagen
proteoglycans
Fibronectin
tenascin
what receptor binds to ecm that is required for expression of things like collagen and tenascin?
interns eg alpha v beta 5
why is an intact membrane needed for tooth development ?
because mesenchyme must attach to it to make odontoblasts- will disintegrate once odontoblasts are made
what is in an intact membrane ?
collagen
tenascin
syndacan
