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Repro Week 2 > OCPs > Flashcards

OCPs Flashcards

1
Q

what two hormones are used in OCPs

A

estrogen and progesterone

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2
Q

what do estrogens do to cholesterol, LDL and HDL levels?

A

LDL down
cholesterol down
HDL up

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3
Q

how does estrogen affect the clotting system?

A

increases production of clotting factors in the liver

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4
Q

what is estrogen effect on bone?

A

anti resorptive

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5
Q

name the three synthetic estrogens for OCPs

A

ethinyl estradiol
diethylstilbestrol
mestranol

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6
Q

name the three progesterone synthetics for OCP use

A

etonogestrel
levonorgestrel
norethindrone

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7
Q

what is the goal of OCPs?

A

to maintain chronically elevated estrogen and progesterone to trick body into not ovulating

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8
Q

name three effects progesterone has to prevent pregnancy

A

inhibit endometrial development
increased cervice mucus to prevent implantation
negative feedback to hypo pit axis

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9
Q

what is the cyclic OCP cycle?

A

1 week placebo and three weeks regular pill…will get monthly bill

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10
Q

what is the extended cycle OCP?

A

1 week placebo and 11 weeks regular pill…one period every 3 mos

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11
Q

what are some favorable effects of OCPs not directly related ot preventing pregnancy?

A

decrease bleeding, lighter periods, decrease dysmenorrhea decrease acne

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12
Q

what two types of cancer mean OCP is contraindicated?

A

liver and breast

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13
Q

what three types of cancer do OCPs help with?

A

ovarian
endometrial
colorectal

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14
Q

what three drugs induce CYP3A4 and decrease effectiveness of OCPs?

A

rifampin
carbamazepine
phenytoin

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15
Q

what class of drugs decreases OCP effectiveness by affecting gut?

A

abx decrease gut bacteria that are needed to increase enterohepatic circulation and increase absorption of OCPs

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16
Q

what is the plan B pill named?

A

levonorgestrel

17
Q

what is moa of levonorgestrel as plan B?

A

super high dose of progesterone and leads to blockage of ovulation you hope

18
Q

what is the other emergency pill to take after intercourse?

A

ulipristal

19
Q

what is med used to abort?

A

mifepristone

20
Q

what is MOa of mifepristone as abortant?

A

anti progesterone which is needed to maintain the endometrium during pregancny so the endo will necrose and die

21
Q

in addition to mifepristone, what else to give for abortion and why?

A

misprostol to help uterine contract and force out junk

Repro Week 2 (9 decks)

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