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Repro Week 2 > Female Pharm > Flashcards

Female Pharm Flashcards

1
Q

what is the MoA of leuprolide?

A

it is a GnRH agonist that actually desensitizes the pituitary to GnRH

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2
Q

what is the first med to give in infertility rx?

A

leuprolide

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3
Q

what is goal of giving leuprolide in infertility?

A

to wipe slate clean of hormones

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4
Q

once you give leu[rolide in infertility rx, what is next?

A

give hCG and rFSH

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5
Q

what is the MoA of clomiphene?

A

estrogen antagonist so it inhibits the negative feedback that estrogen has on the HPG axis

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6
Q

what is the drug that inhibits estrogen action on HPG axis?

A

clomiphene

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7
Q

when do you give clomiphene in infertility rx? why?

A

during the follicular phase to induce the LH surge

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8
Q

what are side effects of clomiphene? why these?

A

mood swings and hot flashes…because of post menopausal like effect of losing estroge

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9
Q

what is another SE of clomiphene?

A

VTE

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10
Q

how do you treat secondary hypogonadism in males?

A

clomiphene or gonadotropins

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11
Q

what do you use to treat obesity associated infertility?

A

anastrozole

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12
Q

what is MoA of anastrozole?

A

aromatase inhibitor

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13
Q

explain how aromatase inhibitors work to fix infertility?

A

block conversion of testosteron to estradiol so increase testosterone levels

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14
Q

where is common location for turning testosterone into estradiol?

A

in adipose tissue, hence why obese ppl may be infertile

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15
Q

name the five uterotonic drugs to give during labor

A 
misprostol
dinoprostone
carboprost
oxytocin
methylergonovine
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16
Q

what is MoA of misoprostol/dinoprostine in labor?

A

they are prostaglandin stimulators that lead to more calcium release and contraction

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17
Q

what is intracellular pathway for contraction of SM in labor?

A

phospholipase C activates IP3 and this increases calcium

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18
Q

what is MoA of carboprost in labor?

A

PGF2 receptor agonist that activates PLC

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19
Q

what is MoA of mehtylergonovine in labor?

A

serotonin agonist that activates PLC

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20
Q

what are tocolytics?

A

drugs given to stop uterine contractions

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21
Q

what are four drug classes that are tocolytics?

A

B agonist
CCB
NSAID
Ca2 binder

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22
Q

name the b agonist used as tocolytic

A

terbutaline

ritodrine

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23
Q

name the CCB used in tocolytic

A

nifedipine

24
Q

name the NSIAD used as tocolytic?

A

indomethacin

25
Q

what is the Ca binder used as tocolytic?

A

MgSO4

26
Q

what three drug classes can you give for PMS/PMDD?

A

OCPs
leuprolide
SSRIs

27
Q

what is issue in PMS/PMDD?

A

body doesnt handle fluctuations in estrogen and porgestoeron well

28
Q

how does leuprolide work in preventing issues in PMS/PMDD?

A

prevents release of FSH/LH and therefore you do not get any estrogen or progesterone

29
Q

how do OCPs work in preventing issues in PmS/PMDD?

A

keep estrogen and progesterone high so you dont get fluctuations

30
Q

what can you do to help with symptoms of menopause?

A

give OCPs or progesterone replacement

31
Q

givin estrogen replacemtn in menopause comes with what risks?

A

endometrial hyperplasia

32
Q

how do OCPs help with endometriosis?

A

inhibit growth of endometrial tissue and inhibit the HPG axis

33
Q

what is MoA of ulipristal?

A

inhibits the HPG axis and reduces endometril tissue growth by being a progesterone agonist

34
Q

what is the MoA of danazol?

A

inhibits the HPG by increasing free testosterone through binding up the SHBG

35
Q

how can leuprolide help with endometriosis?

A

downregulates the GnRH and inhibits gonadotropin release so you dont get endometrial growth as extensive as usual

36
Q

how do aromatase inhibitors help with endometriosis?

A

they inhibit estrogen synthesis by the endometrial tissue

37
Q

name the two aromatase inhibitors used for endometriosis?

A

letrozole and anastrazole

38
Q

what do you give for infertility issues in PCOS?

A

clomiphene

39
Q

how does clomiphene help with infertility in PCOS?

A

it slows the increased pulsatile frequency of the GnRH and restores the normal cycle of hormones

40
Q

what are four drugs to give for PCOS hirsutism issue?

A

spironolactone
OCPs
flutamide
finasteride

41
Q

how do flutamide and spironolactone help with hirsutism?

A

block the testosterone and DHT androgen receptors

42
Q

how does finasteride help with hirsutism?

A

blocks 5a reductase so no T into DHT

43
Q

how do OCPs help with hirsutism?

A

stimulate expression of SHBG so decrease free testosterone

44
Q

what is the first class of meds used in most breast cancer?

A

SERMs

45
Q

what are the SERMS for BC?

A

tamoxifen and raloxifene

46
Q

how does tamoxifen work for BC RX?

A

competitively antagonizes the estrogen receptors on the breast tissue

47
Q

what is SE of SERM rx?

A

increased risk of VTE

48
Q

aside from SERMs what else is use in rx of BC?

A

aromatase inhibitors

49
Q

how do aromatase inhibitors help with BC?

A

inhibit the changing of androgen into estrogen

50
Q

when will aromatase inhibitors not be effective in rx of BC?

A

in premenopausal women

51
Q

why are aromatase inhibitors not effective in rx of BC in premenopausal women?

A

no estrogen is made to disinhibit the HPG so it will keep working to make more hormones

52
Q

what SERM is best for BC?

A

tamoxifene

53
Q

what SERM is best for bone growth?

A

raloxifene

54
Q

what SERM is best for hypothalamus issues?

A

clomphene

55
Q

is the SERM used for BC pro or anti estrogen?

A

anti estrogen

56
Q

is the SERM used for osteoporosis pro or anti estrogen?

A

pro

57
Q

is the SERM used for hypothalamus issues pro or anti estrogen?

A

anti estrogen

Repro Week 2 (9 decks)

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