Occupational health Flashcards
Define toxicology
The study of negative effects of chemicals on living things
What considers a substance to be toxic x2
How much of it is necessary to cause harm
How easily it can enter the body
State 4 routes of entry of a toxin
Inhalation, ingestion, injection, absorption through the skin
State what happens to chemicals in the body x4
Distribution
Metabolism- broken down into smaller compounds
Storage- for a long time
Excretion- through feces and urine
Define toxicity and describe its 2 types
Toxicity is the poisonous nature of any substance
High toxicity- substances that can cause harm following exposure to very small amounts
Low toxicity- substances that cause harm following exposure to large amounts
Describe Paracelsus’s fundamental rule of toxicology
Only the dose required makes the difference between a cure and a poison
Describe dose and maximum response
Once the maximum reaction is reached, increasing the dose doesn’t change the reaction
Differentiate between acute and chronic toxicity
Acute- last up to 96 hours, it is brief and sudden
Chronic- long period of exposure of up to 3 months
Define LD50 and LC50
LD50- a dose which when ingested injected or applied directly kills half of the test subjects
LC50- the concentration of a chemical in a test atmosphere that kills half the test subjects within one hour when inhaled
State 3 phases of poisoning
Chemical exposure phase
Toxicokinetic phase is how body handles the toxin > excretion
Toxicodynamic phase is the signs and symptoms of toxic agent >toxicity
Cause of occupational skin disease x4
Irritants
Mechanical
Physical
Biological
Define contact dermatitis and state it’s two subtypes
Inflammation of the dermal layer of the skin characterized by redness crusting and swelling
Primary irritant contact dermatitis
Allergic contact dermatitis
Describe the 2 pulmonary tests
X-rays
Spirometry- screening tests that measures airway resistance to airflow
Define vital capacity and state what its abnormality implies
The maximum volume of air that can be exhaled after maximum inhalation
Reduced VC implies airway obstruction
Define residual volume and state what its abnormality implies
The volume of air remaining in the lungs after maximum forceful expiration
Increase in RV implies airway distention and air trapping disease ie emphysema
Define asphyxiant and describe its two types
It is a chemical substance that causes unconsciousness or death when inhaled
Simple- interfere with gas exchange and displace O2 in the air eg nitrogen
Chemical- interfere with O2 transport by Hb eg hydrogen cyanide
Exposure sources of hydrogen cyanide x3
Chemical burning
Fumigation
Autopsy room activities
Define pneumoconiosis and state its 3 types
It is a disease resulting from dust in the lungs which causes a tissue reaction
Silicosis- crystalline silica
Asbestosis
Coal worker pneumoconiosis
Describe coal worker pneumoconiosis and what it results in x2
Black lung which develops in workers who work underground and get exposed to carbonaceous dust
Results in fibrosis and emphysema
Define silicosis and 2 characteristics
Chronic lung disease caused by inhalation of unsafe levels of silica in dust
Pulmonary function is normal but may develop into massive fibrotic lesions
Describe 3 types of silicosis
Acute; 1-3 years
Accelerated; 5-15 years
Chronic; 20-45 years
Define exposure limits PEL, IDLH, STEL
Permissible exposure limit- concentration of a substance in the air
Short term exposure limits- 1 hour free of exposure between 15 minute exposure intervals four times a day
Immediately dangerous to life and death- max airborne concentration which would not interfere with ability to escape
Define asthma and state 3 responses of airways to irritants
Reversible generalized obstruction of airways
Bronchospasm
Increased production of mucus in airways
Cough
State 4 causes of occupational skin diseases
Irritants- acids and allergens
Mechanical- friction and bruising
Biological- plants and insects
Physical- heat ad cold