Obstetrics 2 Flashcards
Can sodium valproate be used in pregnancy for epilepsy?
NO
___________ are important in maintaining the ductus arteriosus in the fetus and neonate.
Prostaglandins are important in maintaining the ductus arteriosus in the fetus and neonate.
Are NSAIDs used in preganancy?
NSAIDS are generally avoided in pregnancy unless really necessary (e.g. in rheumatoid arthritis). They are particularly avoided in the third trimester, as they can cause premature closure of the ductus arteriosus in the fetus. They can also delay labour
WHat is used for HTN in pregancy
Beta blocker- labetalol
Pregnancy
Beta-blockers can cause:
- Fetal growth restriction
- Hypoglycaemia in the neonate
- Bradycardia in the neonate
ACE Inhibitors and Angiotensin II Receptor Blockers
Can these be used in pregancy?
Medications that block the renin-angiotensin system (ACE inhibitors and ARBs) can cross the placenta and enter the fetus. In the fetus, they mainly affect the kidneys, and reduce the production of urine (and therefore amniotic fluid). The other notably effect is hypocalvaria, which is an incomplete formation of the skull bones.
no
ACE inhibitors and ARBs, when used in pregnancy, can cause:
- Oligohydramnios (reduced amniotic fluid)
- Miscarriage or fetal death
- Hypocalvaria (incomplete formation of the skull bones)
- Renal failure in the neonate
- Hypotension in the neonate
The use of _____ during pregnancy can cause withdrawal symptoms in the neonate after birth. This is called ______ ______ ________ (NAS). NAS presents between 3 – 72 hours after birth with irritability, tachypnoea (fast breathing), high temperatures and poor feeding.
The use of opiates during pregnancy can cause withdrawal symptoms in the neonate after birth. This is called neonatal abstinence syndrome (NAS). NAS presents between 3 – 72 hours after birth with irritability, tachypnoea (fast breathing), high temperatures and poor feeding.
Warfarin may be used in younger patients with ….
Warfarin may be used in younger patients with recurrent venous thrombosis, atrial fibrillation or metallic mechanical heart valves
can you use warfarin in pregancy
no
Warfarin crosses the placenta and is considered teratogenic in pregnancy, therefore it is avoided in pregnant women. Warfarin can cause:
- Fetal loss
- Congenital malformations, particularly craniofacial problems
- Bleeding during pregnancy, postpartum haemorrhage, fetal haemorrhage and intracranial bleeding
The use of sodium valproate in pregnancy causes _____ ____ ______ and _________ ___
The use of sodium valproate in pregnancy causes neural tube defects and developmental delay.
should valproate taken in girls
no
Lithium is particularly avoided in the first trimester, as this is linked with ______ ______ ________. In particular, it is associated with_____ _______, where the tricuspid valve is set lower on the right side of the heart (towards the apex), causing a bigger right atrium and a smaller right ventricle.
Lithium is particularly avoided in the first trimester, as this is linked with congenital cardiac abnormalities. In particular, it is associated with Ebstein’s anomaly, where the tricuspid valve is set lower on the right side of the heart (towards the apex), causing a bigger right atrium and a smaller right ventricle.
Can you use Selective Serotonin Reuptake Inhibitor in preganacy
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used antidepressants in pregnancy.
. SSRIs can cross the placenta into the fetus. The risks need to be balanced against the benefits of treatment. The risks associated with untreated depression can be very significant.
Women need to be aware of the potential risks of SSRIs in pregnancy:
- First-trimester use has a link with congenital heart defects
- First-trimester use of paroxetine has a stronger link with congenital malformations
- Third-trimester use has a link with persistent pulmonary hypertension in the neonate
- Neonates can experience withdrawal symptoms, usually only mild and not requiring medical management
Isotretinoin is a retinoid medication (relating to vitamin A) that is used to treat severe acne
IT can not be used in pregnancy
WHy?
Isotretinoin is highly teratogenic, causing miscarriage and congenital defects. Women need very reliable contraception before, during and for one month after taking isotretinoin.
Name the medication that should not be used in pregnancy
Non-Steroidal Anti-Inflammatory Drugs
Beta-Blockers- except labetolol
ACE Inhibitors and Angiotensin II Receptor Blockers
Opiates
Warfarin
Sodium Valproate
Lithium
Isotretinoin (Roaccutane)
Selective Serotonin Reuptake Inhibitors?
What is Postpartum Haemorrhag
Postpartum haemorrhage (PPH) refers to bleeding after delivery of the baby and placenta. It is the most common cause of significant obstetric haemorrhage, and a potential cause of maternal death. To be classified as postpartum haemorrhage, there needs to be a loss of:
- 500ml after a vaginal delivery
- 1000ml after a caesarean section
Postpartum Haemorrhage
It can be classified as:
- Minor PPH – under 1000ml blood loss
- Major PPH – over 1000ml blood loss
Major PPH can be further sub-classified as:
- Moderate PPH – 1000 – 2000ml blood loss
- Severe PPH – over 2000ml blood loss
PPH can also be classified as
It can also be categorised as:
- Primary PPH: bleeding within 24 hours of birth
- Secondary PPH: from 24 hours to 12 weeks after birth
There are four causes of postpartum haemorrhage, remembered using the “Four Ts” mnemonic:
- T – Tone (uterine atony – the most common cause)
- T – Trauma (e.g. perineal tear)
- T – Tissue (retained placenta)
- T – Thrombin (bleeding disorder)
Risk Factors for PPH
- Previous PPH
- Multiple pregnancy
- Obesity
- Large baby
- Failure to progress in the second stage of labour
- Prolonged third stage
- Pre-eclampsia
- Placenta accreta
- Retained placenta
- Instrumental delivery
- General anaesthesia
- Episiotomy or perineal tear
Preventative Measures of PPH
Several measures can reduce the risk and consequences of postpartum haemorrhage:
- Treating anaemia during the antenatal period
- Giving birth with an empty bladder (a full bladder reduces uterine contraction)
- Active management of the third stage (with intramuscular oxytocin in the third stage)
- Intravenous tranexamic acid can be used during caesarean section (in the third stage) in higher-risk patients
