objective 4 (2) Flashcards
produced with normal metabolic processes
acids
what is the organ that plays an essential role in acid/base balance?
kidneys
what conditions can lead to acid base imbalances?
diabetes, COPD, kidney disease, vomiting and diarrhea
what is the normal blood pH?
7.35-7.45
pH less than 7.35
acidosis
pH greater than 7.45
alkalosis
an increased in H+ concentration lead to…
acidity
a decrease in H+ concentration leads to…
alkalinity
the higher the pH…
the lower the H+ concentration
the lower the pH…
the higher the H+ concentration
1
most ACIDIC
14
most BASIC
ADDITION of H+ will…
increase ACIDITY and lower pH
ELIMINATION of H+ will…
promote ALKALINITY and rise pH
what are the 4 mechanisms that the body will use to maintain normal balance of acids and bases in the blood?
buffer system
respiratory system
renal system
is the fastest-acting system and the primary
regulator of acid–base balance
buffer system
act chemically to change
strong acids into weaker acids or to bind to acids and neutralize
their effect
buffers
what is the major buffer system for acid base balance?
bicarbonate-carbonic acid system
carbonic acid
chief acid
bicarbonate
chief base
- The amount of CO2 in the blood directly relates to carbonic acid concentration
and subsequently to H+ concentration - CO2 is a potential acid; when dissolved in water, it becomes carbonic acid (CO2
+ H2O = H2CO3). Increase in CO2 = increase in acid in bloodstream (LOWER
pH) & decrease in CO2 = decrease in acid in bloodstream (HIGHER pH). - As a compensatory mechanism, the respiratory system acts on the CO2 + H2O
side of the reaction by altering the rate and depth of breathing to “blow off”
(through hyperventilation) or “retain” (through hypoventilation) CO2. - will respond within couple minutes to change in pH, maximal
effectiveness seen within hours.
respiratory response
- Under normal conditions, the kidneys reabsorb and conserve all of
the bicarbonate they filter. The kidneys can generate additional
bicarbonate and eliminate excess H+ as compensation for acidosis. - The body depends on the kidneys to excrete a portion of the acid
produced by cellular metabolism. Thus the kidneys normally excrete
an acidic urine (average pH is 6).
*is relatively slow (hours or days), but in chronic
conditions (COPD) can maintain balance indefinitely
renal response