Obesity/Metabolic

Question 1

Cause of type 1 diabetes?

Answer 1

autoimmune destruction of B cells by cell mediated immunity (cytotoxic T cells)

Question 2

type 2 diabetes is caused by?

Answer 2

peripheral insulin resistance- increased insulin secretion-amyloid deposit in pancreas by amylin (peptide released with insulin)

Question 3

Leg pain in a type 2 diabetic during exercise?

Answer 3

athersclerosis

Question 4

Cause of polyneuropathy in diabetics?

Answer 4

hyperglycemia

Question 5

• pathogenesis of chronic ulcers in diabetics
• glycosylation of basement membrane proteins contributes to this

Answer 5

microvascular disease

Question 6

pathogenesis of diabetic kidney disease?

Answer 6

-deposition of basement membrane proteins (may become glycosylated), increased mesangium results in glomerusclerosis and formation of kimmelstiel-wilson nodules (nodular glomerulosclerosis

Question 7

metabolic pathway responsible for formation of cataracts in diabetics?

Answer 7

Aldose reductase pathway (glucose–>sorbitol)

Question 8

why are diabetics at increased risk for UTI’s?

Answer 8

glucose in urine provides enriched medium for bacteria to grow in

Question 9

Children who are born to mothers with diabetes are at risk for_________ immediately following birth

Answer 9

hypoglycemia