Obesity II Flashcards
What are the causes of the obesity epidemic? (5)
*The basic cause of obesity is simple and well understood: Energy intake simply outstrips energy expenditure
*There are two key factors in the last four decades that have contributed to this–
(1) The development of an obesogenic environment–
(2) A preexisting genetic disposition to become obese
*Notice how disposition to become obese does not become important until one is placed in an obesogenic environment
*The obesogenic environment has developed over the last forty years
*It is evident in most industrialised nations (and now in developing nations as well) but especially in North America, Europe and Australia
*It is intimately connected to all aspectsof our daily lives
*It is characterised by a reduction in physical activity and an increase in the availability and consumption of processed foods
If ppl are in an env that its hard to get food, no one will become fat
What is the obesogenic environment?
*The obesogenic environment has developed over the last forty years
*It is evident in most industrialised nations (and now in developing nations as well) but especially in North America, Europe and Australia
*It is intimately connected to all aspects of our daily lives
*It is characterised by a reduction in physical activity and an increase in the availability and consumption of processed foods
How does physical activity affect the obesogenic environment? (3)
*In the last 40 years people in Western nations have reduced physical activity through increasing car usage and TV viewing
*The advent of digital media has added to the number of sedentary leisure activities, increasing peoples total screen time exposure (and hence the amount of time they are inactive)
*Occupation
–Most occupations have become less physically demanding
–This is a consequence of increasing mechanisation and a shift in the type of work we do, namely away from manufacturing/agriculture to service industries
*In the 1950’s around 55% of the labour force in the US were involved in jobs which had a physical component
*Today, only 32% of the labour force are in such jobs
–One consequence of this is that we expend less energy at work, on average, than in the past
How does the way we travel to work affect the obesogenic environment?
*In the US, less than 10% of trips outside the home are made on foot or bicycle
*Obesity rates tend to be higher in areas which are primarily reliant upon the car
*Think of the impact that urban design has on obesity
–Size of gardens, ‘cul-de-sac’effect, walking vs. car distance
*Poor neighbourhoods also have fewer parks and people are often more reluctant to use them because of fear of crime
*Whilst in the past we may have walked to work, people now use their car, often by necessity
*This again reduces energy expenditure
How do our leisure activities affect the obesogenic environment? (3)
*The main leisure activity of Westerners is TV
*In 1960 the average person watched 13hrs/wk, now it is 26hrs/wk (and this does not include other devices)
*The amount of time spent watching TV is moderately correlated with obesity
*More TV = less physical activity = greater obesity
*This relationship is particularly pronounced in children and is also associated with snacking
*In addition, children are also the target for TV advertising for high fat/sweet foods
*Young children are unable to discern the difference between an advert and ‘factual’ TV
Is physical activity a cause or correlation of the obesogenic environment?
*The evidence we have reviewed suggests an association(at the population level) between obesity and activity
*Is there any stronger (causal) evidence?
–Longitudinal studies come closest to addressing this
*In Finland a 5yr follow-up study of 12,000 people found that physical activity at baseline was the best predictor of weight gain at follow-up (i.e., no exercise put you at greater risk)
*Similar findings have been obtained in the US Nurses study (prospective longitudinal study of 68,000 nurses) and with longer follow-up periods (10yrs)
*Overall, the consilience of evidence points to one conclusion -less physical activity contributes to higher rates of obesity
How does school contribute to the obesogenic environment?
*In the US during the 1980’s (and later in other Western nations) there was a strong drive to cut costs in public education
–This led to the loss of school exercise programs
–The sale of school playing fields
–The introduction of fast-food into school canteens (outsourcing of catering)
–Fast-food advertising in schools (revenue)
–Exclusive contracts to provide soft-drinks (vending machines etc) in schools
–Similar story in the UK (with school lunches such as turkey twizzlers, chips & coke
How do demographic shifts contribute to the obesogenic environment?
*Many families (irrespective of their composition) have all their adult member/s working
–A consequence of this is a greater reliance upon processed food (restaurants, fast-food, TV dinners, etc)
*Processed food is typically higher in fat, sugar and salt, and the consumer has little or no control over the ingredients in that food
How do processed foods contribute to the obesogenic environment?
*Most processed foods are highly palatable
–So you are likely to eat more of them than blander foods and consume them in preference to healthier alternatives
–They contain larger quantities of fat, sugar and salt
*Often this fat is in the form of ‘trans-fats that are advantageous due to long shelf life but have adverse effects on blood cholesterol
*Fat has more calories than sugar and protein, so eating an extra gram of fat is far more deleterious for weight control than an extra gram of sugar or protein
*Eating foods that contain lots of added sugar may have several negative effects on the body (it may: spike blood sugar, up-regulate fat production, cause inflammation, and shorten inter-meal intervals)
*Excess salt intake appears to contribute to hypertension
–Soft drinks consumption is independently associated with obesity and it results in incomplete caloric compensation
*Soft drink consumption is a risk factor for Type II diabetes and osteoporosis
How does variety contribute to the obesogenic environment?
*Rats given a large variety of palatable foods become obese (cafeteria diets)
*Humans are in a similar situation
–Palatable foods are available at any time in most places
–Supermarkets stock an incredible variety of different foods
–New products constantly come on-line
How does portion size contribute to the obesogenic environment?
*Portion sizes have increased
*If people are given larger portions they eat more
*Similarly, for a given portion size, if packaging size is increased, consumption also increases
*Mean portion sizes in the US are (outlet for outlet) 25% larger than in Europe
*As also are plate sizes, recipe book portions and even guide books focus more on portion size in the US
*Supersizing is a common marketing ploy whereby a small extra cost is accompanied by an extra-large size portion
*This ploy is very profitable
Is it really the environment?
*The evidence is very strong that it is
–Notably obesity has been increasing in the last 40 years which is clearly too short a time for genetic changes to occur
*Pima Indians
–In the US they have veryhigh rates of obesity (mean BMI=33.4; 80-85% obese) and diabetes
–Genetically similar Pima Indians living in rural Mexico have both lower rates of obesity (mean BMI=24.9) and diabetes
–The primary difference between these two genetically similar populations is diet and exercise
*Migration studies
–US residents of African, Caribbean & Latin American descent all have significantly higher BMI’s, than their relatives in their country of origin
–In all of these studies, where genetically similar groups are compared in their new or native country, what differs is diet and exercise
How do the environment and genes contribute to obesity?
*All of the environmental factors reviewed above interact to generate what has been termed an obesogenic environment
*However, some people still manage to remain thin in this environment while others gain weight
*Thus, some individuals appear more susceptible to the obesogenic environment than others -that is they may have a genetic predisposition to weight gain
What is genetic susceptibility to weight gain? (6)
*Body weight is affected by many factors which are likely to be influenced by our genetic make up
*It should not be surprising then to find that genetic influences on bodyweight are ‘polygenic’
*Twin, adoption and family studies all show that an individual’s risk of obesity (all measures) is increased when that person’s relative/s are obese
–Having one obese parent increases a child’s risk of being obese by 40%, two obese parents by 80%
–Identical twins raised apart (vs raised together) suggest that around 70% of the variance in body weight is controlled by genetic factors
–Adoption studies indicate that a child resembles their biological parents in weight, not their adopted parents and this holds especially so for the biological mother
What is genetic predisposition to weight gain? (5)
*Genetic influences that predispose to obesity operate on:
*Energy balance -Thermogenesis, Liver metabolism (of fat)
*Feeding behaviour –Fat preferences, Leptin resistance, Craving
*Skeletal muscle growth -Rate of growth
*Satiety regulation -Serotonin levels, POMC levels
*Fat cell numbers/differentiation
–Obese individuals maybe born with more (BMI < 30 have around 20-25 billion fat cells; BMI 30+ have around 100-125 billion)
*In other words many if not all of the pathways that we know to be involved in regulating body weight