Obesity And Eating Disorders Flashcards
What is meant by obesity?
Medical term for accumulation of body fat which may have a negative effect on health.
List 8 things which high body fat increases the risk of.
Depression, asthma hypertension, CHD, dyslipidemia, type 2 diabetes, arthritis, stroke, infertility
What are 8 causes of obesity?
Calories - portion size, energy density Food -more refined carbs/processed food Physical activity -more sedentary Reduction in sleep - alters glucose metabolism, increases appetite, decreases energy expenditure Greater mental stress - people change their eating habits Micronutrient deficiencies Alteration to microbiome - dysbiosis Genetic factors
Explain why sleep deprivation contributes to insulin resistance.
Increases catecholamines and contributes to insulin resistance
Explain why alterations to the microbiome may cause obesity.
Increased energy harvest via fermentation, bacterial endotoxins can alter hosts metabolism
What is the difference between hyperplastic and hypertrophic obesity?
Hyperplastic is increased number of fat cells that exist throughout the body caused by the mother eating and excess of calories during pregnancy, it is difficult for the child to develop new fat cells.
Hypertrophic is increase in the size of each fat cell. Linked to diabetes, heart disease and high blood pressure. Fat distribution is around the waist.
What are intra abdominal adipose Or VAT tissue?
More metabolically active, large insulin resistant adipocytes, higher density of adrenergic receptors.
What 2 things cause increase circulation of fatty acids?
Decreased in insulin mediated anti-lipolysis and increased catecholamine mediated lipolysis
What does VAT produce?
Large number of hormones (adipokines - cytokines, leptin, adiponectin, resisting and TNF-alpha, IL-6
What does leptin do? What produces leptin and why is it produced?
Satiety hormone, regulates appetite, energy balance
Adipocytes when they are full of triglycerides
What is the link between leptin and neuropeptide y?
Leptin down regulates neuropeptide y leading to decreased hunger, increased activity and increased thermogenesis.
What is peripheral leptin resistance?
Leptin can modify insulin sensitivity, tissue metabolism, stress so overtime changes in metabolisms lead to abdominal weight gain.
What are 5 factors that involved the feeling of satiety?
Mechanical stretch receptor of stomach via vagus nerves Ghrelin, leptin and adiponectin produces Glucagon like peptide in GIT Neuropeptide y Insulin, glucagon
How does ghrelin regulate satiety?
When ghrelin is low it indicates fullness and when it is high it increases hunger. Dieting increases ghrelin which is why it stimulates hunger.
How does adiponectin regulate hunger?
Lean subjects have more adiponectin than obese people so it trigger satiety.
What are the 7 metabolic actions of insulin?
Stimulates synthesis of triglycerides from free fatty acids Inhibits release of free fatty acids Increases glycogen in liver Inhibits glucogenesis Stimulates glucose uptake Stimulates glycogen synthesis Reduces hunger
What happens during insulin resistance?
Lipolysis is not inhibited which causes an excess of fatty acid
As Visceral fat increases adiponectin production decreases so less oxidation of fatty acids and less clearance of excess fat in tissues and insulin is less sensitive.
Increases making glucose from glycogen and prevents glucose from being converted and stored as glycogen