Obesity

Question 1

Physical activity represents which % of energy expenditure?

Answer 1

15-30% (most is basal metabolic rate)

Question 2

Which gene variant was identified in Dundee to be associated with obesity in children?

Answer 2

FTO

Question 3

Obesity has been implicated in which cancers (7)

Answer 3

Esophagus, stomach, gallbladder, liver. colorectal, endometrium, kidney.

Question 4

Which hormone is secreted by fat that makes us feel “full”?

Answer 4

Leptin

Question 5

Name the only registered weight-loss drug in the UK?

Answer 5

Orlistat

Question 6

Orlistat’s MoA?

Answer 6

Inhibits lipase which blocks absorption of dietary fat

Question 7

Which type of bypass surgery is this?

Answer 7

Roux-en-Y bypass

Question 8

Is Roux-en-Y surgery malabsorptive or restrictive?

Answer 8

Both

Question 9

Is a vertical sleeve gastrectomy restrictive or malabsorptive?

Answer 9

Restrictive

Question 10

What’s the process by which the body’s resting metabolic rate declines as weight is loss?

Answer 10

Adaptive thermogenesis

Question 11

Why is it harder to lose weight/ keep weight off when you were once obese?

Answer 11

The resting metabolic rate declines (due to adaptive thermogenesis)

Question 12

What’s the most effective intervention for long-term weight loss?

Answer 12

Bariatric surgery