Formatives

Question 1

What’s the average weight of the thyroid gland?

Answer 1

25-30g

Question 2

What nerve can be potentially damaged during thyroid surgery?

Answer 2

Recurrent laryngwal nerve

Question 3

What is the most biologically active thyroid hormone?

Answer 3

fT3

Question 4

What is the main regulatory method of thyroid hormone release?

Answer 4

Free T3 negative feedback on pituitary / hypothalamus

Question 5

What is the main binding globulin for thyroxine?

Answer 5

TBG

Question 6

Thyroxine has no effect on cardiac muscle, true or false?

Answer 6

False (sensitises to sympathetic stimulation)

Question 7

Thyroxine has no effect on reproductive tissues, T or F?

Answer 7

False

Question 8

A goitre is only present in hyperthyroidism, true or false?

Answer 8

False

Question 9

An underactive thyroid causes heat intolerance, true or false?

Answer 9

False - causes COLD intolerance

Question 10

All ATDs should be avoided in pregnancy, true or false?

Answer 10

False - PTU in 1st and carbimazole in 2/3rd

Question 11

If a patient still needs thyroxine 1 year after delivery she is likely to need it life-long, true or false?

Answer 11

True (25-50% of patients will become persistently hypothyroid)

Question 12

A woman in early pregnancy with known hypothyroidism should double her dose of thyroxine immediately, true or false?

Answer 12

False - increase by 25mcg initially. Later, most patients will require 50% greater dose than they were on while not pregnant

Question 13

Gestational diabetes usually presents in the 1st trimester, T/F?

Answer 13

False - usually in the third

Question 14

Methyldopa is a good option for BP control in hypertensive pregnant women, T/F?

Answer 14

True - avoid ACEi

Question 15

ACEi and statins are safe to use in pregnancy, T/F?

Answer 15

False

Question 16

Maternal hyperinsulinaemia causes increased foetal growth, T/F

Answer 16

False - it’s maternal hyperglycaemia which causes excess growth

Question 17

The corpus luteum secretes hCG, T/F?

Answer 17

False - it secretes progesterone, the hCG comes from the placenta

Question 18

After a pregnancy with G-DM, the risk of T2DM is 10% within the next 10 years, T/F?

Answer 18

False - 50% within 10 years, 80% if mother is obese

Question 19

Dopamine inhibits release of prolactin, true or false?

Answer 19

True

Question 20

ACTH exerts its peripheral effects via IGF-1, true or false?

Answer 20

False, ACTH releases cortisol

Question 21

Surgery is the 1st line therapy for prolactinoma, T/F?

Answer 21

False - usually medical (e.g. cabergoline)

Question 22

Acromegalic headache is usually due to tumour compression, true or false?

Answer 22

False - usually vascular in origin, not compression

Question 23

A 1mg overnight suppresion test is the best screening test for Cushing’s, T/F?

Answer 23

True

Question 24

Cortisol is a posterior pituitary hormone, T/F?

Answer 24

False

Question 25

A baseline serum:urine osmolality of >2 avoids needs for water-deprivation test, T/F?

Answer 25

False* - the urine will be less concentrated as the patient cannot concentrate urine

*lecturer did not explain this

Question 26

Testosterone can cause polycythaemia, T/F?

Answer 26

True