Obesity Flashcards
What does obesity mean ?
Excessively high amount of body fat or adipose tissue
In how many children is obese?
1 in 10
Who has the highest rates of obesity?
Hispanic & African Americans
Higher rates if obesity comes from?
Low educated & low income patients
Who is more at risk? South or north?
South
Etiology and pathophysiology
For obesity is (2)?
Body weight beyond physical requimenrs
Abnormal increase and accumulation of fat cells
Those who have obesity problems increased the risk of (3)?
Increase in number ( hyperplasia ) and size ( hypertrophy ) of adipocytes ( fat cells )
Adipocytes can hold up to how much of their volume? And why do they grow?
1000x
In order to accommodate large increases in lipid storage
There are two types of obesity? What are they?
Primary & secondary
Primary obesity is what?
Increase calories in > than calories used
What is secondary obesity? (4)
This one is mainly what?
Chromosomal/congenital anomalies
Metabolic problems
CNS lesions & disorders
Drugs
Medical problem caused the weight gain
Genetic predisposition is what percentage of obese patients?
70%
There has been evidence that the gene ___ and body mass index has increased chances of getting obesity
FTO
( fat mass and obesity associated gene )
What part of the brain play a huge part in triggering appetite and energy for a person?
Hypothalamus
The hypothalamus, gut and adipose tissues help synthesis (2) that stimulate or inhibit appetite
Hormones & peptides
Neuropeptides Y is very dangerous because it’s a powerful what?
And causes what if it’s imbalanced?
Appetite stimulant
Leads to overeating and obesity
What are the 2 hormones that we will be talking about regarding the hypothalamus?
Leptin & Ghrelin
What does leptin do?!(2)
Suppresses appetite
Increase fat metabolism
Since leptin helps suppresses appetite and increase fat metabolism, how does this effect obese patients?
Obese patients will have high leptin levels meaning that have leptin resistance
What is ghrelin (3)
- regulates appetite by inhibiting leptin
- thought to play a part in complusive eating
- non obese person
( ghrelin high when they are hungry and decrease after eating )
What are two major consequences of obesity?
- Increase in fat mass
- Production of adip okines
What is adiopokines?
Contribute to (3)
They may disrupt (2)
They are substance made from adipocytes
Insulin resisitance, dyslipidemia, hyerptension
Immune factors & predispose to certain cancers