Immunologic Disorders Of Kidney Flashcards
What are the 5 immunologic disorders of kidney?
Glomerulonephrtisis
Acute poststreoptococcal Glomerulonephrtisis
Chronic glomerulonephritis
Good pasture syndrome
Rapid progressive glomerulonephritis ( RPGN )
What is glomerulonephritis and it effects?
Inflammation of Glomeruli
Both kidneys equally
Although glomerulonephritis mainly inflames the glomeruli, it can also effect?
Tubular and interstitial change
With Vascular scarring
And hardening ( glomerulosclerosis ) of the kidneys
Glomerulonephritis is the what 3rd leading cause of what in the United States?
ESRD
What are associated conditions that can cause glomerulonephritis? (4)
Kidney infections
Nephrotix drugs
Immune disorders
Systematic diseases
There are two types of Glomerulonephrtisis what are they and examples? (2)
(2,3)
Acute
- sudden symptoms & revisibke
Chronic
- slow
- progressive
- irreversible renal failure
Acute poststreoptococcal Glomerulonephrtisis is most common in who? (3)
Children (5-7)
Young adults
Older adults (60)
What does acute psotstreptococcal Glomerulonephrtisis develop?
1-6 weeks after an infection of tonsils, pharynx, skin by nephrotoxic strains of group A B hemolytic streptoccoci
( from antibodies to strep antigen )
So since it’s infections of tonsils pharynx or skin, it’s important to ask the patient of past history of?
Sore throat or fever
Although the exact mechanism is unknown for APSGN, how does it effect the glomeuri? (3)
Tissue injury occurs as the antigen antibody complexes
And goes into the glomeruli
Causing inflammation
What are clinical manifestations of APSGN (9)
S as SMOKE!!!
E AS IN EDD
Edema
Hypertension
Oliguria ( small amount of urine )
Hematuria ( bleeding urine )
Proteinuria ( protein in urine )
Fluid retention
Abdominal or flank pain
Asymptotic
Smoky urine
Anagram to help me remember clinical manifestations for APSGN (9)
Edds
Hyper
Orgy
Head
Provides
Fluid
Flanky
Ass
Smoke
At first Edema will a show up where ___ then moves towards total body including ____(2)
Periorbital ( eyes )
Ascites & peripheral
Why does smoky urine occur in clinical manifestations for ASPGN?
Bleeding in upper urinary tract
Why does hypertension occur in ASPGN?
Because of the increase EFV ( cashing that edema )
How do you diagnosis ASPGN? (7)
Example or explain each
Second one example is most important!!
History & physical assessment
Streptozyme test
(Antistreptolysin-O ( ASO) tigers)!!
Renal biopsy - confirms
Dipstick urinalysis
Urine sediment microscopy
( erythrocytes & protein )
BUN& CREATINE test
- renal impariment
Nursing Interprofessional & management of ASPGN
over how many people recover completely with conservative treatment?
95%
Management of ASPGN is? (4)
Examples or explain each
Rest
- decreased inflammation & HTN
Restrict Sodium & fluids ( administer diuretics )
- describe edema
Restric protein
- decreased BUN
Antibiotics
Streptococcal infection present
Prevention of ASPGN?
Early diagnosis & treatment of sore throats & skin lesions
If the patient is positive with streptoccoci culture what do we want to give and teach patient?
As well what to do with skin infections?
Patient should do?
Antibiotics & take entire prescription
Personal hygiene
( stop spread )
What is chronic Glomerulonephritis?
Syndrome of permanent and progressive renal fibrosis
Which can lead to ESRD
Some people who develop chronic glomerulonephritis will never or either have what? (2)
( think of syndrome )
Never had history of kidney disease
Inheredied ( alport syndrome )
Symptoms occur what for chronic glomerulonephritis?
Slowly and unware
Chronic glomerukobephritis
Clinical manifestations are? (5)
Hematuria
Proteinuria
Urinary execration of formed elements ( RBCS, WBCS, CASTS)
Increase BUN
Increase Creatinine
