Disorders Of Stomach And Upper Small Intestine Flashcards
What is peptic ulcer disease?
Condition characterized by erosion of gi mucuous from the digestive action of HCI acid and Pepsin
What are the 2 types of peptic ulcers?
Acute vs chronic
What is acute peptic ulcer (3)
Superficial Erosion
Minimal inflammation
Short duration
- resolved quickly when cause is identified and removed
What is chronic peptic ulcer disease? (2)
Muscular wall erosion with formation of fibrous tissues
More common than acute erosions
Chronic can be in two locations, which are?
Gastric and duodenal
Chronic gastric ulcer is ?(5)
What are risk factors (4)
Superficial
Pain 1-2 hours post meals with foods
Peak age 50-60 ( women )
Increased obstruction
Increased mortality
Risk factors are
- h.pyloric, medications, smoking, bile reflux
Chronic duodenal ulcers is?(6)
What are risk factors (4)
80% of all ulcers
Deep
Pain 2-4 hours post meals
Pain decrease with food
Peak 35-50 men
Associated with stress and chronic disease
Risk factors
- h. Pylori, ETOH( alcohol), smoking, increase HCL acid
H. Pylori is a major risk factor why?
% gastric
% duodenal
How is it transmitted?
Mainly found in who?
Life span?
What does it produce?
80%
90%
Oral or oral / fecal to oral
African Americans & Hispanic
Long
Urease
What are the 3 overall risk factors for peptic ulcers?
H. pylori
Medications
Life styles
Medications induced injury such as? (3)
NSAIDS
Corticosteroids/anticoagulants
Life styles factors for peptic ulcers are? (5)
Alcohol
Smoking
Caffeine
Psychological distress
Stress related muscoal disease in upper gi bleed
What are diagnostic studies for peptic ulcers?(5)
(3)(3)(3)(3)(1)
Endoscopy
- direct visualization
- obtain specimens for h.pylori ( urease )
- monitor toward healing
Noninvasive h. Pylori : serology, stool, breathe test
Barium contrast, high fasting serum gastric levels, secretin stimulation
Labs : CBC, liver enzymes, serum amylase
Stool- blood
Treatment goals of peptic ulcers are?
Decreased gastric acidity and en goes muscoal defense mechanism
What is conservative care for peptic ulcer? (6)
Adequate rest
No smoking/alcohol
Stress management
Dietary modifications
Pain mangement ( NO NSAIDS/ASPIRN!! ( unless with PPI, H2 recotor, misoprostol )
Endoscopy evaluation follow up 3-6 months
Drug therapy for peptic ulcers (5)
PPI
Antibiotic therapy
( peptiod bismuth )Bismuth alone or combined with tetracycline & Metronizadole
Cytoprotective drug therapy
Antibiotic therapy for the?
Do for how long ( days?)
If allergic use what?
H. Pylori 14 days of PCN ( if allergic, use metronidazole )
Cytoprotective drug therapy
What is the drug?
Helps how?
Works best in?
Bonds with?
Sucralfate
Protects esophagus, stomach and duodenum
Low ph; 1-3 hours before and after antacid
Cimetidine, digoxin, warfarin, phenytoin and tetracycline
What are the 3 complications of drug therapy?
Is it emergent? Yes or no
Hemorrhage
Perforation
Gastric outline obstruction
Emergent !!
Out of the 3, what is most common?
What is the most lethal?
Hemorrhage
Perforation
Why is perforation so lethal from the drug therapy complication?
Causing?
Intensity will amount to?
GI contents will spill into the peripheral cavity
Causing
Suddenly severe abdominal pain; going to the back and shoulders with no relief of food or antacids
Bowl sounds become absent ; nausea and vomiting
Respiratory shallow
Pulse increase & weak
Intensity will amount to duration of spillage
Perforation; the belly will be rigidly like and that is?
Rigid, board like abdomen
We need surgery!!
Peritinistisis
If perforation isn’t untreated you will get what within 6-12 hours?
Bacterial peritonitis
Your immediate focus with perforation in peptic ulcer is to?
Stop the spillage and restore blood volume
What will we do for perforation? (5)
NGT for aspiration and gastric suppression
IV fluids and blood
Central line
Small - self sealing
Large - surgery & closure