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Obstetrics and Gynecology > OB Drugs > Flashcards

OB Drugs Flashcards

1
Q

B2 adrenergic receptor agonist

Relaxes uterine smooth muscle

A

Ritodrine
Salbutamol
Terbutaline

Tocolytic

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2
Q

Inhibits uterine COX-1 enzyme

Blocks PGF2 alpha & PGE2 formation

A

Indomethacin
NSAIDs

Tocolytic

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3
Q

Ca channel antagonist
Voltage gated L- channels

Relaxes uterine smooth muscle

A

Nifedipine

Dihydropyridine
Tocolytic

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4
Q

Competition at Ca channels

A

Magnesium sulfate

Tocolytic

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5
Q

Oxytocin pituitary neuropeptide receptor antagonist

A

Atosiban

Tocolytic

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6
Q

Converted to methyl NE centrally to decrease adrenergic outlfow by alpha-2 agonistic action from cns

Reduced total peripheral resistance
Decreased systemic blood pressure

Used in controlled preeclampsia

A

Methyldopa

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7
Q

Directly relaxes arteriolar smooth muscle but not venous smooth muscle

Used in HTN of pregnancy

A

Hydralazine

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8
Q

Magnesium sulfate

1.7-3.5

A

Therapeutic range

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9
Q

Mag Sul

2.5-5.0

A

ECG changes
Inc PR interval
Widened QRS

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10
Q

Mag Sul

4-5

A 
Reduced deep tendon reflex
Ventilatory changes begin 
Drowsiness
Sedation
Slurred speech
Nausea
Double vision
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11
Q

Mag Sul

> 0.5

A

Loss of deep tendon reflex

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12
Q

Mag Sul

> 7.5

A

Respiratory paralysis
CNS Depression
Sinoatrial and AV Node blockade

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13
Q

Mag Sul

> 12

A

Complete heart block

Cardiac arrest

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14
Q

Increases sodium permeability of uterine myofibrils indirectly stimulating contraction of uterine smooth muscle

A

Oxytocin

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15
Q

Oxytocin SE

A

Uterine hyperstimulation and FHR abnormalities
Abruptio placentae
Uterine rupture
Water intoxication (>40 mu)

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16
Q

Rapid IV oxytocin causes

A

Hypotension

17
Q

Blocks myometrial oxytocin receptor

A

Atosiban

18
Q

Atosiban SE

A

Chest pain
Vomiting
Nausea

19
Q

A tocolytic is a

A

Labor supressant

20
Q

Cervical ripening and labor inducing drugs

A

Dinoprostone PGE2
Misoprostol PGE1
Mifepristone antiprogesterone
Oxytocin

21
Q

Misoprostol induces

A

Mobius syndrome

Obstetrics and Gynecology (18 decks)

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