O&G Infections In Pregnancy

Question 1

4 features of congenital rubella syndrome

Answer 1

Congenital deafness
Congenital cataracts
Congenital heart disease (PDA and pulmonary stenosis)
Learning disability

Question 2

features of congenital CMV infection

Answer 2

Fetal growth restriction 
Microcephaly
Hearing loss
Vision loss
Learning disability 
Seizures

Question 3

Toxoplasmosis pathogen

Answer 3

Toxoplasma gondii

Question 4

Toxoplasma gondii transmission

Answer 4

Cat faeces

Question 5

Slapped cheek syndrome

Answer 5

Parvovirus B19

Question 6

Classic triad of features of congenital toxoplasmosis

Answer 6

Intracranial calcification
Hydrocephalus
Chorioretinitis

Question 7

Complications of Parvovirus B19 infection in pregnancy

Answer 7

Miscarriage
Intrauterine death
Severe foetal anaemia
Hydrops fetalis
Maternal pre-eclampsia like syndrome (mirror syndrome)

Question 8

Intrapartum abx prophylaxis for GBS

Answer 8

IV benpen 3g at onset of labour and 1.5G 4 hourly until delivery

Question 9

Mode of delivery for mother’s with HIV

Answer 9

Viral load at 36 w
< 50 copies/mL vaginal
> 50 copies/mL or hep C - c section with intrapartum IV zidovudine at 38 weeks

Question 10

Newborn from HIV+ve mother Mx

Answer 10

Treat with ART within 4 hours

Low risk : zidovudine monotherapy 2-4w
High risk: triple ART (zidovudine. Lamivudine, nevirapine) for 4 weeks

Direct viral amplification by PCR to confirm or deny infection