nucleotide synthesis

Question 1

nucleotides are made up of

Answer 1

nitrogen base, 5 c sugar, phosphate group

Question 2

pyrimidines

Answer 2

cytosine, uracil, thymine (one ring

CUT

Question 3

purine

Answer 3

adenine, guanine (two rings)

Question 4

sugar structure /(2)

Answer 4

always pentose, either ribose OR deoxyribose

check structure

Question 5

nucleoside

Answer 5

vbase and sugar. base is added to c1 in b linkage

Question 6

nucleoside base name change

Answer 6

cytidine, uridine,

thymidine, adenosine, guanosine

Question 7

nucleotide

Answer 7

ADD PHOSPHATES to a nucleoside

- atp

Question 8

nucleotide purpose 5

Answer 8

1) energy carrier and storage (atp, gtp)
2) activate compounds for metabolism (udp gucose)
3) allosteric effectors
4) components in cofacctors (nad, nadp)
5) in nucleic acids (rna, dna)

Question 9

purine metabolism

Answer 9

cytoplasm

glucose 6 p - ribose 6 p - PrPP - invert - glycine - ring closure - imp

imp - amp - atp
imp - gmp - gtp

Question 10

purines catabolism

Answer 10

broken down to uric acid, not very soluble

long pathway

Question 11

gout

Answer 11

uric acid solubility - it crystalizes in serum and accumulates in joints.

treatment: allopurinol which competitively inhibits xanthine oxidase (so less uric acid made)