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Med Chem > Nucleotide Metabolism > Flashcards

Nucleotide Metabolism Flashcards

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1
Q

Nucleoside

A

Base + (deoxy)ribose

Naming: -osine ending for purines, -idine ending for pyrimidines

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2
Q

Nucleotide

A

Base + (deoxy)ribose + one or more Pi

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3
Q

Purine biosynthesis

A

Adenine and guanine are synthesized as adducts of 5-phosphoribosyl 1-pyrophosphate (PRPP)

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4
Q

Reduction of ribonucleotides

A

Ribonucleotides can be reduced to deoxyribonucleotides

NADPH supplies electrons to ribonucleotide reductase (becomes active when reduced), which reduces the ribonucleotide

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5
Q

Biosynthesis of dTMP

A

Thymidine nucleotides are derived from dUMP

dUMP is methylated by thymidylate synthase to form dTMP

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6
Q

Salvage reactions

A

Recycle free bases into nucleotide monophosphates

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7
Q

Precursor of purines

A

Inosine

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8
Q

Precursor of thymine and cytosine

A

Uracil

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Med Chem (37 decks)

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