Nucleotide Metabolism Flashcards
1
Q
Nucleoside
A
Base + (deoxy)ribose
Naming: -osine ending for purines, -idine ending for pyrimidines
2
Q
Nucleotide
A
Base + (deoxy)ribose + one or more Pi
3
Q
Purine biosynthesis
A
Adenine and guanine are synthesized as adducts of 5-phosphoribosyl 1-pyrophosphate (PRPP)
4
Q
Reduction of ribonucleotides
A
Ribonucleotides can be reduced to deoxyribonucleotides
NADPH supplies electrons to ribonucleotide reductase (becomes active when reduced), which reduces the ribonucleotide
5
Q
Biosynthesis of dTMP
A
Thymidine nucleotides are derived from dUMP
dUMP is methylated by thymidylate synthase to form dTMP
6
Q
Salvage reactions
A
Recycle free bases into nucleotide monophosphates
7
Q
Precursor of purines
A
Inosine
8
Q
Precursor of thymine and cytosine
A
Uracil
