Nucleoside Reverse Transcriptase Inhibitors

Question 1

Nucleoside Reverse Transcriptase Inhibitors prototype

Answer 1

Zidovudine (AZT, Retrovir, Aztec)

Question 2

Zidovudine indications

Answer 2

Management of adults with symptomatic HIV infection in combination with other antiretrovirals; prevention of maternal-fetal HIV transmission.

Question 3

Zidovudine actions

Answer 3

A thymidine analogue that is activated to a triphosphate form, which inhibits the replication of various retroviruses, including HIV

Question 4

Zidovudine route, onset, peak

Answer 4

Oral, varies, 30-90 min;

IV, rapid, end of infusion

Question 5

Zidovudine adverse effects

Answer 5

Headache, insomnia, dizziness, nausea, diarrhea, fever, rash, bone marrow suppression.