Nonnucleoside Reverse Transcriptase Inhibitors

Question 1

Nonnucleoside Reverse Transcriptase Inhibitors prototype

Answer 1

Nevirapine (used in adults and children 2 months and up)

Question 2

Nevirapine indications

Answer 2

Treatment of HIV-1-infected patients who have experienced clinical or immunological deterioration, in combination with other antiretrovirals. (Treatment of patients with documented AIDS or ARC/AIDS Related Complex with evidence of opportunistic infections).

Question 3

Nevirapine actions

Answer 3

Binds to HIV-1 reverse transcriptase and blocks replication of the HIV by changing the structure of the HIV enzyme.

Question 4

Nevirapine route, onset, peak

Answer 4

Oral, rapid, 4 h

Question 5

Nevirapine adverse effects

Answer 5

Headache, nausea, vomiting, diarrhea, rash, liver dysfunction, chills, fever.