Anti-Hepatitis B

Question 1

Anti-Hepatitis B prototype

Answer 1

Adefovir

Question 2

Adefovir indications

Answer 2

Treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in alanine aminotransferase and aspartate aminotransferase or histologically active disease.

Question 3

Adefovir actions

Answer 3

Inhibits hepatitis B virus reverse transcriptase, causes DNA chain termination, and blocks viral replication.

Question 4

Adefovir route, onset, peak, duration

Answer 4

Oral, rapid, 0.6-4 h, unknown

Question 5

Adefovir adverse effects

Answer 5

Headache, asthenia (abnormal physical weakness or lack of energy), nausea, severe to fatal hepatomegaly with steatosis (abnormal retention of lipids within a cell), nephrotoxicity, lactic acidosis, exacerbation of hepatitis B when discontinued.