nucleic acid and genetic info L4 Flashcards
DNA —->mRNA=
transcription
mRNA—> protein=
translation
sugar of DNA
deoxyribose
bases of DNA
adenine- thymine
cytosine- guanine
RNA sugar
ribose
RNA bases
adenine- uracil
cytosine- guanine
nucleotides are made up off
pentose sugar
phosphate group
nitrogenous base
purine bases=
adenine, guanine
pyrimidine bases =
cytosine, thymine, uracil
other role of nucleotides
ATP carrier
signalling cAMP
enzyme cofactor
what is the directionality of DNA
5-3
what are the phosphate group and sugar group in adjacent nucleotides linked by
phosphodiester bonds
what bonds form between specific base pairs
hydrogen
what charged is phosphate groups
negative
where do you inherit mitochondrial DNA from
materally
how is DNA packaged
around histones
what is a nucleosome
a group of 8 histones
DNA is an acid or base
acid
Euchromatin=
unpacked beads on a string in a transcribing chromosome
heterochromatin=
packed fibre in a non-transcribing chromosome
chromatin=
collection of nucleosomes
what is within a chromosome
supercoiled chromatin fibre associated with non-histone proteins forming a chromosomal scaffold
what determines the shape of a given chromosome
chromosomal scaffold
centromere=
point of attachment to the mitotic spindle
chromatid
one copy of a duplicated chromosome
telomere=
protects the ends of the chromosome during replication
which arm is the short arm
P arm
which arm is the long arm
q arm
what is the human genome pattern
diploid
how many chromosomes
46
how many different autosomes
22
how many sex hormones
2
how many homologous pairs
23
when do chromosomes become visible
during replication
2 parts of cell cycle
division and interphase
3 parts of interphase
G1
S
G2
what is the resting phase of a cell
G0
what happens in G1 phase
protein making and growing
what happens in S phase
chromosomes copied
what happens in G2
the cell checks DNA and gets ready to start dividing
cell division=
mitosis
5 phases of mitosis
prophase prometaphase metaphase anaphase telephase
what happen in prophase
chromosome condensation
dispersal of nucleoli
seperation of centrosomes and formation of mitotic spindle
what happens in prometaphase
fragmentation of the nuclear envelope
attachment of spindle microtubles (MTs) to centromeres
chromosomes start to move towards cell centre
what is the mitotic spindle formed from
micotubules
how do the microtubules attach to the centromere of the chromosome
via the kinetochore
what happens in metaphase
chromosome alingment at the metaphase plate
what happen in anaphase
chromosomes (chromatids) move to opposite cell poles
What happens in telephase
chromosomes uncoil
nucleoli develope and fuse
disassembly of spindle
reformation of the nuclear envelope