Nu 735Anemia Flashcards
Hematopoisis
On going formation blood cells
Erythropoises (EPO)
lHormone regulate RBC
Linked to O2
Produced in Kidney
Apoptosis> Abcess of EPO leading to cel death
Iron, B12, Folate (B9)
Iron > “fuel hormone”
Erythroblast require productio of : B12 and Folate B9
Erythropoiesis.> Deficiensy in B12 and Folate
RBC
Hgb: blood’s O2 carrying capacity
Hct: volume of RBC to whole blood
MCV: Size RBC
MCH: amount of Hgb in RBC
MPV: average of plt
Reticulocyte Count: **immature **RBC > measure production and rease RBV
Mean Corpuscular Volume (MCV) =
Determine Size RBC
MCV< 80 : micro
a. Iron Deficiensy Anemia ( Not enough Iron to make Hgb leading fewer RBC formed
MCV: 80 to 100 = Normocytic
MCV>100 macrocytic
a. Folate / B9 deficiecy
B12 deficiency
Reticulocyte Count
- “Immature RBC”
Measures Production of RBC by bone marrow and -
Elevated RC = Hemolysis (Hemolytic Anemia, Acute Blood loss; Vitamin B12 B9 defifiensy)
*** Low RC **> Erythropoiesis > 2/2 bone marrow due to reduction erythroblast .
Lactate Dehydrogenase (LDH)
Ensyme Found in all body tissues
Catalyzes to pyruvate (production of glycolysis )
Elevated Hemolitic Anemia b/c it’s floating around
Haptoglobin
Plasma protenin produce in Liver
Clear free RBC
Low : Hemoliti Anemia
Hemolitic Anemia Labs
LDH = High
Haptoglobin = low
Reticolyte count = Hight
Ferritin and Fe +
Ferrtin is protein that contains iron
**Primary stored iron **
Fe require for cell groth
Low Iron leading to Toxicity and Death
Transferrin, TIBC % Saturation
Measure capacity to transfer Iron
Reticular Counnt deficiensy
Hypo- Proliferative Anemia
**Key Points: **
* 75 % of all cases has
* Low Reticulocytes with **normal **RBC Morphology
* Reticulocyte production index <2
*** Causes: **
* Mild to mod Fe deficiency
* Marrow damage
* Inadeuate EPO production
* Impaired O2 d/t metabolic Diseases
Maturation Anemia
Reticular Count Formation
Low Reticular Count +
Both Macrocytic /Microcytic Anemia
RC normal index <2
Types of Anemia
Iron Def Anemia
TX Plan
- Fe Sul 300 to 325 mg po TID
Duration : 3month
Improve around 2 month
Increased storage in around 6 month
Considratiion: **
Take on empty stomach
Avoid antacids or milk
Add Vit C (increase absorption)
Venofer
Indication: GI intolernce or malabsortion
Duratio 5 days