Dyslipidemia Flashcards
Cholesterol Essential Understanding
- Cholesterol is fatty substance manufactured in the Liver
- Carried on Lipoproteins via the bloodsteam
- Body needs cholesterol to build healthy cells
- High level cholesterol can increase risk heart disease
Hyperlipidemia or Lipid Disorder
Two Forms
Primary (Familial ) : Inherited
Secondary: (Acquired) : eating fast food
3 diffrent Lipoproteines all together Makes Total Cholesterol
In Fasting Serum, cholesterol is carried primary on 3 different Lipoproteins
* VLDL > Your TG
* LDL
* HDL
Low-Density Lipoproteisn (LDL)
- Aka “ Lousy” form cholesterol
- **Primary Function **responsible for depositing cholesterol within arteries
How to lower LDL
Easing Healthy Diet
* Soluble Fiber : decrease LDL
* Avoid Saturated and trans fat
* Maintain a healthy weight
LDL : Goal
<100 mg/dl with no CHD
<70 with CHD
Hight-Density Lipoprotein (HDL)
- Good cholesterol or “Healthy” cholesterol
- Helps get rid of LDL
- High levels of HDL reduce the risk of MI
How to increase HDL
- Regular Physical Activity
- DO no smoke
- Maintain healthy weight
- 1-2 ETOH can help
*
Goal for HDL
> 40
Triglycerides (TD)
- Not a type of cholesterol
- Strored from of fat in our bodies
- VLDL lipoprotein carries TG
- High levels increased risk of ( Heart deases, stroke, Hypertriglyceridemia )
How to Lower TG
- Limit Sugar, ETOH and fat; Simple carbs
- Physical activities
- Healthy weight
- Do no smoke
- Optimize glucose control in DM
Goal TG
<150
Tendinous Xanthomas
- Increased levels of TG
- Generally familial form of Hyperlipidemia
Tx Plan age 0 to 19
- Lifestyle modifications to preven ASCVD
- Dx of familial hypercholesteromia
- Statin
age 20 to 39
- As above
- LDL >/= 160
- statin
40 to 75
LDL >/= 70 to <190 w/o DM
10 yrs ASCVD %
Statin for Bordeline to hight risk (5 to 20%)
Age >75
Clinical assessemnt and conditions
Dyslipidemai Tx plan
**LDL >/= 190
High intesity Statin
Tx plan
DM and 40 to 75 yrs
Moderate to high intesity statin
High Intesity
Atorvastating 40 to 80 mg
Rosuvastatin 20 to 40
Moderate Intensity
Atorvastin 10 to 20
Rosuvastatin 5 to 10
Simvastatin 20 to 40
Low intensity
Simvasting 10 mg
Dyslipidemia Tx Options
Statin
Bile acid binders
Nicotinic acid “ niacin “
Fibric Acids
Choelsterol absorption inhibitors
Fish oil
