Nu 735 SKIN Flashcards
Cellultis
What is it ?
*** Acute Inflammatory **Condition of skin characerized by Localized:
* Pain, Erythema, Swelling, Heat
* Usualy infection of LE but can be anywhere
Cellulitis caused
- Indigenous Flora (Colonizing Skin ) or
- Exogenous Bacteria : Wide variety.
- Access Epidermitis: from cracks, abrasions, cuts, burns, bites.
- If skin compromised can develop cellulitis
- MRSA Replacing MSSA inpatien & outpatient settin
*
Purulent VS Non-Purulent
- Purulet Cellulits: MRSA/MSSA - Focal infection
- Non-Purelent : S Pyogenes > Rapid Spread > Diffuse Associates Lyphagitis
Cellulits
*Most common Portal of Entry :
Healthy person LE Due to
- **Web intertrigo with fissuring **
-
Tinea Pedis : Complicated By
Intertrigo is not inflammatory skin condition it lead to fungal to** bacterial i**nfection
Cellulitis
Most common bacteria
> ** Gram positive cocci : **
Group A beta hemolytic &
S. aureus
S Pyogenes
non -purulent
Rapidly spread
Associate w Lymphagitis
Cellulits :
Rare Bacterian
**Gram Negative **
**Pseudomonas Aeruginosa **
Occurs in :
* Hospitanlized and Immunocompromized pt
* Steping on Nail : Deep Tissue Injury
* **Pseumomonas = DTI **
Cellulitis:
Recurrent
**Streptococcal Cellulitsi : Group A, C, or G **
- Venous Statis, Saphenous Venectomy From CABG
- Chronic Lymphedema.
- Lymph node dissection
- Milroy Disease (disease that effect the function of lymphatic System )
CEllulits :
Elderly Population
With DM and PVD
Group B Step: **Streptoccocus Agalactiae **-
Cellulitis Clinical Manifestations
Classic Findings:
* Pain, Erythema, Swelling, Heat
* Begins as Small Tender Patch
* Expands over Hours : 6 to 36 HRs
Cellulits : Labs
- Leukocytosis
- At least Neutrophilia
B/L Cellulitis
- Very uncommon
- DDx Statis Dermatitis
- **Consider Crytococcal **
Worsening Infection
- Chills, Fever, malaise
- Lymphagtitis and Lymphdenopathy
Cellulitis : Complications
Septicemia
And
Shock
Cellultis :
Animal or Human Bites
- Augementin
- Ampicillin
- Cefoxitin ( 2nd Generation )
Cellulits TX:
Empirical TX
- Cover for both Strep and Steph : Gm +
* - Cefazolin 1gram TID (1st generation Cef) OR
- Rocephin
Cellulitis DX
- Clinical Observation:
- R/O Statis Dermatitis , DVT vs Cellulitis
- Definitive DX: Wound culture and Gram’s stain( from wound)
- Skip Biopsy: Immunocompromised pt looking for uncommon Bacteria
*
Cellulits :
Pseudomonas Aeroginosa
**** Most common Penetrating injury Stepping on Nail
**ABG Coverage: **
** Gram negative **
- **Aminoglycoside **(Gentamycin )
- 3rd gen Cephalosporin (Cefriaxone; Cefotaxine, Cephaxide)
- Semi-Synthetic PNC (Zosyn )
- Fluoroquinolone (Ciprofloxacin; Levofloxacin )
- For 7 to 10 days
Diabetic Foot Ulcer
Overview
- Leading cause of Non-Traumatic LE ambutation
- Major source of Morbidity
DM Ulcer :
**Reason of Increased incidence of ulcer Involves
Multiple Factors **
* Neuropathy & Abnormal foot Biomechanics : Interferes with normal Protective Mechanisms
* PAD & Poor wound Healing : Impeded Integrity
DM Ulcers: Risk Factors
Male, DM > 10 yrs, smoking, Visual impairment, Poor Glycemic control, Dialsys
**Attentin to Risk Factors :
PVd, smoking, Dyslipidemia, HTN, Obesity, Glycemic Control: Impove
DM Ulcers: Common Areas
Great Toe
Metatarsophlangeal
Plantar
14 to 24% Undergo Amputation
DM Foot Ulcers:
Clinical Findings
- Asymptomatic vs Symptomatic
- Plantar Surgace: Most common Site
- Nerupatic Ulcer vs Infection (Cellulitis around )
- Gas Gangrene w/c Clostriial
DU: Infectious Etiology
Multiple Organisms:
* **Aerobic Gram-positive Cocci **: Most common (Staphylococus species; Streptococcus species; Group A, B, MRSA )
* Aerobic & Anaerobic Gram negative Bacilli
Empirical Coverrege
DM Ulcer : TX Plan
- Identification of High-Risk Patient
- Education and Prevention
- Anual Foot Exam
- Screening the Asymtomatic for PAD ( > 50 yrs with DM; ABI (Ankle Brakial Index ultrasound check for PVD for high risk pt
DM: Patient Education
- Daily Inspection feet and fot Hygiene
- Avoidance of self TX
- Prompt consultation (podiatry)
DM Ulcer: Risk Factor Modifications
- Orthotic Shoes and Devices
- Callus Management and nail Care
- Prophylactic Measures: Reduce abnormal bone abnormalities pressure
DM Ulcer DX
I**nitial Imaging **
* Plain Radiography (XRAY )
* MRI (R/O Osteomyelitis)
* Nuclear Medicine tagged WBC ( if pt has metal in a body)
laboratry: CBC, CMP, Wound & BC
DM Ulcer
DX: Mild Infection tx
PO **Cephlosporin (Augmentin ) **
DM Ulcer: Prior Hx MRSA
Clindamycin (Baware C/Diff)
Docycyline or Bacrim (watch DM pt can lead to AKI )
DM Ulcer: Severe Cases
**Empiric Coverage IV ABT: **
Cover : Staph, Strep, Gram negative Aerobic and Anaerobes
Vancomycin + Beta Lactam Inhibitors (Zosyn or Cephapin ) or Carbapenem
**Vancomycin + Fluroquinolone (Ciprofloxacin; Levoflaxacin target (gm - ) + Flagyl (anarobic coverage)
*** Vancomycin and Cephapime (4th ) most common pharmacy does
Dm Ulcer: Infectious Etiology
Multiple Organisms :
* **Aerobic Gram (+) Cocci **- most common (Stephyloccocus species, Steptococcus Species, A+ B , MRSA )
* Aerobic + Anaerobic Gr (-) Bacilli