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BCH 203 > NT receptors > Flashcards

NT receptors Flashcards

1
Q

NTs act on specific cells . This is called their——-.

A

selectivity

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2
Q

List the General 2 types of receptors

A

IONOTROPIC

METABOTROPIC

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3
Q

IONOTROPIC receptors are also called—-?

A

Ligand gated channels

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4
Q

Define the 2 types of receptors

A

IONOTROPIC: are ion Channel act as receptors too

METABOTROPIC: The receptor molecule, ion channel and ion protein are all separate

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5
Q

Differentiate between the 2 types of receptors in terms of life span,and rate of synaptic response

A

IONOTROPIC: fast post synaptic response
-responses are short lived

METABOTROPIC: response is a long lived and they act with slow postsynaptic response

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6
Q

METABOTROPIC receptors are bound——- that eventually cause——

A

to G-proteins

ion channels to open

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7
Q

List the Ach receptors and what type of receptors they are

A

Muscarinic
-metabotropic

NICOTINIC
Ionotropic

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8
Q

How many subunits of muscarinic receptors do we have and what type of Gprotein do they use

A 
M1: Gq,G11
M2: Gi,Go
M3: Gq,G11
M4: Gi,Go
M5: Gq,G11
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9
Q

Effect of muscarinic receptors on second messengers

A 
M1: Increase +IP3 , +DAG
M2: inhibit adenyl cyclase
M3: Increase +IP3 , +DAG
M4: inhibit adenyl cyclase
M5: Increase +IP3 , +DAG
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10
Q

Location of m1,3,5 receptors besides CNS neurons

A

M1: sympathetic post ganglionic neurons and some presynaptic sites
M3:exocrine glands,vessels,smooth muscles,endothelium
M5:vascular endothelium

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11
Q

Location of M2,4 receptors besides CNS neurons

A

M2: myocardium,some smooth muscles ,some presynaptic sites
M4:vagal nerve endings

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12
Q

List the types of nicotinic receptors

A

Nn,N1, Nm

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13
Q

Location of the types of nicotinic receptors

A

Nn
found in some pre synaptic cholinergic terminals,post ganglionic neurons

Nm
Found in muscle receptors

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14
Q

Nicotinic receptors are muscarinic.

T/F

A

T

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15
Q

What type of subunits do the nicotinic receptors have?

A

Nn: only alpha(2-10) and beta(2-4)subunits

Nn:alpha, beta, gamma,delta, episilon

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16
Q

Mechanism of nicotinic receptors

A

ion channel opens, permitting either one or more specific types of ions (e.g., K+, Na+, Ca2+) to diffuse into or out of the cell.

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17
Q

Effect of the Muscarinic receptors on K,and Ca conductance

A

M2 and M4:increase K; decrease Ca

M1,M3,M5:reduce K;increase Ca

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18
Q

Broad Types of adrenoreceptors

A

alpha and beta

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19
Q

ADRENORECEPTORS. Muscarinic or Ionotropic?

A

Muscarinic

20
Q

Effect of the following oncAMP.
Gq
Gs
Gi

A

Increase
Increase
Decrease

21
Q

There are —— main types of ADRENORECEPTORS, and are - and —, with —- subtypes in total.

A

2

Alpha and beta

9

22
Q

Alpha adrenoreceptors are divided into — with - subtypes and —- with —- subtypes

A

Alpha 1- 3 subtypes

Alpha 2- 3 subtypes

23
Q

Beta adrenoreceptors are divided into ——- subtypes

A

3

24
Q

Alpha-1 adrenoreceptors are bound to - G protein?.
Alpha-2 adrenoreceptors are bound to - G protein?.
Beta 1 adrenoreceptors are bound to - G protein?.
Beta 2 adrenoreceptors are bound to - G protein?.
Beta 3adrenoreceptors are bound to - G protein?.

A 
Q
I
S
S and I
S and 1
25
Q

Locations of alpha 1, beta2, and beta 3 adrenoreceptors?

A

Alpha 1:smooth muscles
Beta 2: smooth muscle and cardiac cells
Beta 3: lipocytes and cardiac cells

26
Q

two major classes of DOPAMINERGIC RECEPTORS are??

And they contain which others??

A

D1 and D2

D1 includes 1,5
-D2 includes 2,3,4

27
Q

Which G proteins do the dopaminergic receptors bind to??

A

D1 like - S

D2 like- I

28
Q

GABA receptors. Metabotropic or Ionotropic?

A

Ionotropic for GABAa

Metabotropic for GABAb

29
Q

Mechanism of GABAA receptors?

A

Increase conductance of Cl channels

30
Q

Which G protein does GABAb use?

A

I

31
Q

GABAa Is An ———-glycoprotein that has a——— structure which Involves—-,—,—,—,—,and — subunits that come together to form an— unit

A

hetero-oligomeric

Pentameric

alpha beta gamma delta epsilon pie

oligomeric

32
Q

Hypnotics, sedatives, anaesthetics, all act on —- receptor

A

GABAa

33
Q

How many subtypes of serotonin receptors Do we have?…which ones are generally inhibitory?…which ones are Ionotropic and which are metabotropic

A

7

1 and 5

Ionotropic-3
Metabotropic-1,2,4,5,6,7

34
Q

What type of G proteins are the serotonin receptors using?

A 
1-I
2-Q
4-S
5-I
6-S
7-S
35
Q

Which subunit of 5-HT1 is not the the other 5-HT1 subtypes? . And how

A

HT1p enteric NS(excitatory)

36
Q

What’s the similarity between 5HT1a,b and d?

And why isn’t f part of it?

A

Found only In blood vessels and CNS

F is found only in CNS, not in blood vessels

37
Q

Location of 5HT-2

A

Found everywhere on that list

38
Q

Where won’t you find 5HT-3 receptors?

A

Blood vessels, platelets, and smooth muscles

39
Q

Similarity between 5-HT3 and 5-HT-4?

A

Absent and present in the same places

40
Q

Similarity between 5-HT5 and 5-HT6?

A

5HT5a and 6 are found only in the CNS
WHILE
5-HT5b isn’t found anywhere on the list

41
Q

Location of 5-HT1c

A

Doesn’t exist anymore

It’s now 5-HT2c

42
Q

Histamine receptors are which types of receptors

A

Metabotropic

43
Q

How many types of histamine receptors do we have?

A

4

44
Q

What type of G proteins are present in the histamine receptors

A

1-q
2-s
3-I
4-I

45
Q

Functions of the histamine receptors

A

1-brain, smooth muscle endothelium,for vascular vasodilation
2-gastric acid secretion , inhibit antibody synthesis
3-autoreceptors , decrease ach,NE, and serotonin release in CNS
4-allergies

BCH 203 (6 decks)

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