NT receptors Flashcards by Iseoluwa Ojo

NTs act on specific cells . This is called their——-.

selectivity

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List the General 2 types of receptors

IONOTROPIC

METABOTROPIC

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IONOTROPIC receptors are also called—-?

Ligand gated channels

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Define the 2 types of receptors

IONOTROPIC: are ion Channel act as receptors too

METABOTROPIC: The receptor molecule, ion channel and ion protein are all separate

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Differentiate between the 2 types of receptors in terms of life span,and rate of synaptic response

IONOTROPIC: fast post synaptic response
-responses are short lived

METABOTROPIC: response is a long lived and they act with slow postsynaptic response

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METABOTROPIC receptors are bound——- that eventually cause——

to G-proteins

ion channels to open

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List the Ach receptors and what type of receptors they are

Muscarinic
-metabotropic

NICOTINIC
Ionotropic

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How many subunits of muscarinic receptors do we have and what type of Gprotein do they use

M1: Gq,G11
M2: Gi,Go
M3: Gq,G11
M4: Gi,Go
M5: Gq,G11

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Effect of muscarinic receptors on second messengers

M1: Increase +IP3 , +DAG
M2: inhibit adenyl cyclase
M3: Increase +IP3 , +DAG
M4: inhibit adenyl cyclase
M5: Increase +IP3 , +DAG

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Location of m1,3,5 receptors besides CNS neurons

M1: sympathetic post ganglionic neurons and some presynaptic sites
M3:exocrine glands,vessels,smooth muscles,endothelium
M5:vascular endothelium

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Location of M2,4 receptors besides CNS neurons

M2: myocardium,some smooth muscles ,some presynaptic sites
M4:vagal nerve endings

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List the types of nicotinic receptors

Nn,N1, Nm

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Location of the types of nicotinic receptors

Nn
found in some pre synaptic cholinergic terminals,post ganglionic neurons

Nm
Found in muscle receptors

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Nicotinic receptors are muscarinic.

T/F

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What type of subunits do the nicotinic receptors have?

Nn: only alpha(2-10) and beta(2-4)subunits

Nn:alpha, beta, gamma,delta, episilon

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Mechanism of nicotinic receptors

ion channel opens, permitting either one or more specific types of ions (e.g., K+, Na+, Ca2+) to diffuse into or out of the cell.

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Effect of the Muscarinic receptors on K,and Ca conductance

M2 and M4:increase K; decrease Ca

M1,M3,M5:reduce K;increase Ca

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Broad Types of adrenoreceptors

alpha and beta

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ADRENORECEPTORS. Muscarinic or Ionotropic?

Muscarinic

Effect of the following oncAMP.
Gq
Gs
Gi

Increase
Increase
Decrease

There are —— main types of ADRENORECEPTORS, and are - and —, with —- subtypes in total.

Alpha and beta

Alpha adrenoreceptors are divided into — with - subtypes and —- with —- subtypes

Alpha 1- 3 subtypes

Alpha 2- 3 subtypes

Beta adrenoreceptors are divided into ——- subtypes

Alpha-1 adrenoreceptors are bound to - G protein?.
Alpha-2 adrenoreceptors are bound to - G protein?.
Beta 1 adrenoreceptors are bound to - G protein?.
Beta 2 adrenoreceptors are bound to - G protein?.
Beta 3adrenoreceptors are bound to - G protein?.

Q
I
S
S and I
S and 1

Locations of alpha 1, beta2, and beta 3 adrenoreceptors?

Alpha 1:smooth muscles Beta 2: smooth muscle and cardiac cells Beta 3: lipocytes and cardiac cells

two major classes of DOPAMINERGIC RECEPTORS are?? | And they contain which others??

D1 and D2 D1 includes 1,5 -D2 includes 2,3,4

Which G proteins do the dopaminergic receptors bind to??

D1 like - S | D2 like- I

GABA receptors. Metabotropic or Ionotropic?

Ionotropic for GABAa | Metabotropic for GABAb

Mechanism of GABAA receptors?

Increase conductance of Cl channels

Which G protein does GABAb use?

GABAa Is An ———-glycoprotein that has a——— structure which Involves—-,—,—,—,—,and — subunits that come together to form an— unit

hetero-oligomeric Pentameric alpha beta gamma delta epsilon pie oligomeric

Hypnotics, sedatives, anaesthetics, all act on —- receptor

GABAa

How many subtypes of serotonin receptors Do we have?…which ones are generally inhibitory?…which ones are Ionotropic and which are metabotropic

7 1 and 5 Ionotropic-3 Metabotropic-1,2,4,5,6,7

What type of G proteins are the serotonin receptors using?

``` 1-I 2-Q 4-S 5-I 6-S 7-S ```

Which subunit of 5-HT1 is not the the other 5-HT1 subtypes? . And how

HT1p enteric NS(excitatory)

What’s the similarity between 5HT1a,b and d? | And why isn’t f part of it?

Found only In blood vessels and CNS F is found only in CNS, not in blood vessels

Location of 5HT-2

Found everywhere on that list

Where won’t you find 5HT-3 receptors?

Blood vessels, platelets, and smooth muscles

Similarity between 5-HT3 and 5-HT-4?

Absent and present in the same places

Similarity between 5-HT5 and 5-HT6?

5HT5a and 6 are found only in the CNS WHILE 5-HT5b isn’t found anywhere on the list

Location of 5-HT1c

Doesn’t exist anymore | It’s now 5-HT2c

Histamine receptors are which types of receptors

Metabotropic

How many types of histamine receptors do we have?

What type of G proteins are present in the histamine receptors

1-q 2-s 3-I 4-I

Functions of the histamine receptors

1-brain, smooth muscle endothelium,for vascular vasodilation 2-gastric acid secretion , inhibit antibody synthesis 3-autoreceptors , decrease ach,NE, and serotonin release in CNS 4-allergies