NSAIDs part 1 Flashcards
Typical NSAIDs block the production of _____, which _____ the nociceptive fibres to stimulation by other inflammatory mediators
prostaglandins; sensitize
Aspirin as an antipyretic: desc MOA
Block PGE2
↓ fever
Aspirin as an anti-platelet: desc MOA
- Irreversible COX-1 inhibitor
- No TXA2→ no platelet aggregation→ easy bleeding
- No PGI2→ platelets aggregate→ clotting
Aspirin is prescribed at low doses as ‘_______’ in those cardio disease
(used more in _______)
blood thinner; in elderly
Aspirin as an analgesic: desc MOA
- Block prostaglandins→ desensitize nociceptive fibres to stimulation
- Analgesic ceiling since blockage of sensitization instead of direct noiceptive activation
Aspirin as an anti-inflammatory: desc MOA
- Block COX→ no PGI2 PGE2
- ↓ vasodilation (thus less heating/redness)
- ↓ Vascular permeability (thus less swelling)
- ↓ Pain
- ↑ Platelet aggregation
Aspirin: >50mg/dL (salicylate toxicity) plasma salicylate conc. What are the adverse effects?
- Tinnitus (ringing in ears)
- Central hyperventilation
- Respiratory alkalosis
- Fever
- Dehydration
- Metabolic acidosis
- Hypoprothrombinaemia
Aspirin: around 160mg/dL plasma salicylate conc. (highest dose)
What adverse effect?
Renal/ respiratory failure
Aspirin is linked to what syndrome? What is it?
Reye’s syndrome.
Swelling of brain (encephalitis) and liver
Symptoms of Reye’s syndrome
- Vomiting
- personality change
- listlessness
- delirium
- loss of consciousness
Reye’s syndrome: ↑ risk if aspirin taken by ____________
children w viral infections
Is naproxen more effective in men or women?
Women
Naproxen is often used for
dysmenorrhoea
Indometacin : strong or weak anti-inflammatory?
Strong
Adverse effects of Indometacin
(elderly more susceptible)
Confusion/ Depression
Psychosis
Hallucination
