Drugs for gout & arthritis Flashcards
1
Q
Drugs for osteoarthritis
A
- Paracetamol
- Intra-articular: hyaluronic acid
- NSAIDs: naproxen, diclofenac, coxibs
- Corticosteroid: prednisolone
2
Q
MOA of hyaluronic acid
A
- reduces pain & stiffness
- shock absorption
- induces biosynthesis of HA & extracellular matrix
- lubrication
- protective coating of cartilage
3
Q
Drugs for gout
A
ACUTE:
- Colcihine (for ACUTE)– most effective in gout
- NSAIDs- Indometacin, Naproxen, Celecoxib, Etoricoxib
- Corticosteroid- prednisolone
Prevention:
1. Allopurinol (1st line) (for hyperuricemia)
2. Probenecid
(for hyperuricemia)
4
Q
Colcihine MOA
- Binds __________
- Prevent __________ into microtubules
- Inhibits __________ & __________
- Inhibits _________ and __________production
A
- Binds tubulin
- Prevent tubulin polymerization into microtubules
- Inhibits leukocyte migration & phagocytosis
- Inhibits leukotriene B4 (LTB4) and prostaglandin production
5
Q
Colcihine works within ______ hrs
A
24-36
6
Q
Colcihine side effects
A
Diarrhoea Nausea Vomiting Abdominal pain Muscle weakness Unusual bleeding Pale lips Change in urine amount
7
Q
Allopurinol MOA
- Inhibit __________
- Decrease __________
- Therapeutic target: __________
A
- Inhibit uric acid synthesis
- Decrease uric acid production
- Therapeutic target: <6.0mg/dL
8
Q
Allopurinol side effects
A
Skin rash Nausea Vomiting Diarrhoea Fever Sore throat Stomach pain Dark urine Jaundice
9
Q
Allopurinol: can start during acute attack?
A
NOOOOO
10
Q
Allopurinol severe effects
A
- Allopurinol hypersensitivity syndrome (AHS)
2. Severe cutaneous adverse reaction (SCAR)
11
Q
Probenecid MOA
- Inhibits ________________
- Inhibits ________________
- Increases ________________
A
- Inhibits proximal tubule anion transport
- Inhibits uric acid re-absorption
- Increase uric acid excretion
12
Q
Probenecid: start ___ wks after an acute attack
A
2-3
13
Q
Probenecid side effects
A
Nausea Vomiting Painful urination Lower back pain Allergic reactions Rash
14
Q
Probenecid: Do NOT use during _____ attack when plasma urate ↑ mobilisation from joints
A
acute
15
Q
Probenecid: Take plenty fluid & keep urine pH>__ to reduce risk of _________
A
pH>6
uric acid nephrolithiasis
