Drugs for skin & soft tissue

Question 1

Most common cause of cellulitis

Answer 1

Group A strep & staph aureus

Question 2

Drugs to treat cellulitis

Answer 2

Cephalexin (PO)

Clindamycin (PO/IV)

Question 3

MOA of Cephalexin

Answer 3

Cell wall synthesis inhibitor

Question 4

Most common side effects of cephalexin

Answer 4

Rash & diarrhoea

Question 5

Which are NOT side effects of cephalexin?

• Steven-Johnsons Syndrome (SJS)
• Thrombophlebitis
• Myopathy
• Photosensitivity
• Allergies

Answer 5

• Myopathy

- Photosensitivity

Question 6

MOA of clindamycin

Answer 6

• Targets 50s subunit of bacteria ribosome

- Targets gram positive, negative and anaerobes

Question 7

Side effects of clindamycin

Answer 7

Anaphylaxis
Pseudomembranous colitis
Superinfection
Nausea
Myopathy

Question 8

Clindamycin is effective against

Answer 8

MRSA

Question 9

Drugs for pressure ulcers

Answer 9

Piperacillin- tazobactam (Zosyn) (IV)

Ciprofloxacin (PO)

Clindamycin (PO/IV)

Vancomycin (PO/IV)

Question 10

MOA of Piperacillin-tazobactam (Zosyn)

Answer 10

• Cell wall synthesis inhibitor (Transpeptidation)

- Disrupts vertical linkages in cell wall

Question 11

Side effects of Piperacillin-tazobactam (Zosyn)

Answer 11

Rash
Diarrhoea
Allergies
Steven-Johnsons Syndrome (SJS)

Question 12

Is piperacillin-tazobactam (Zosyn) safe for pregnancy?

Answer 12

yesss

Question 13

MOA of ciprofloxacin

Answer 13

• DNA synthesis inhibitor

- Targets gram positive, negative and mycobacterium

Question 14

List at least 5 side effects of ciprofloxacin

Answer 14

Anaphylaxis
Tendon rupture
Superinfection
Photosensitivity
Pseudo- membranous colitis
Seizure
Peripheral neuropathy
Hepatotoxicity

Question 15

Contraindications of ciprofloxacin

Answer 15

• Elderly with tendonitis
• Athletes with ruptured tendon
• Cardiac dysrhythmias
• Contraindicated in pregnancy

Question 16

MOA of vancomycin;

and what does it target?

Answer 16

• Cell wall synthesis inhibitor (Transglycosylation)

- Only targets gram positive

Question 17

Side effects of vancomycin

Answer 17

Red man’s syndrome

Nausea, vomiting, anaphylaxis, superinfections, nephrotoxicity, ototoxicity

Question 18

Vancomycin is 1st line for ______

Answer 18

MRSA