NSAIDs, DMARDs, Gout

Question 1

Tx for kawasaki disease

Answer 1

Aspirin

Question 2

Dosage range where aspirin follows first order elimination kinetics

Question 3

Dosage where aspirin has antipyretic and analgesic effects

Answer 3

300-2400 mg/d

Question 4

Dosage of aspirin for anti-inflammatory effect

Answer 4

2400-4000 mg/d

Follows zero order elimination kinetics

Question 5

Toxic and lethal doses of aspirin?

Answer 5

Toxic dose: 150 mg/kg

Lethal dose: 30 g

Question 6

Only IV NSAID

Answer 6

Ketorolac, use restricted to 72 hr

Question 7

For closure of PDA

Answer 7

Indomethacin

Question 8

COX 2 selective NSAIDs

Answer 8

Celecoxib
Etoricoxib
Parecoxib
Rofecoxib
Valdecoxib

Question 9

COX 3 inhibitor, weak COX 1 and COX 2 inhibitor

Answer 9

Paracetamol
Acetaminophen
Phenacetin

Question 10

Antidote for paracetamol

Answer 10

N-acetylcysteine

Question 11

Cytotoxic intermediate of paracetamol

Answer 11

N-acetyl-p-benzoquinoneimine (NAPQI)

Question 12

Toxic and lethal doses of paracetamol

Answer 12

TD: 150 mg/kg
LD: 15 g

Question 13

Inhibits AICAR transformylase and thymidylatr synthetase

Answer 13

Methotrexate

Question 14

DMARD of first choice to treat RA

Answer 14

Methotrexate

Question 15

Binds to TNF -alpha, preventing activation of TNF-alpha receptor

Answer 15

Infliximab
Adalimumab
Etanercept

Question 16

One of its SE is reactivation of latent TB

Answer 16

Infliximab

Question 17

DMARD, Anti-malarial drug Safe for pregnant women

Answer 17

Chloroquine

Question 18

SE of cyclophosphamide. Rescue agent?

Answer 18

Hemorrhagic cystitis, Mesna

Question 19

Causes reversible infertility in men

Answer 19

Sulfasalazine

Question 20

Nonselective, irreversible COX1 and COX2 inhibitor

Answer 20

Aspirin

Question 21

Inhibits microtubule assembly

Answer 21

Colchicine

Question 22

Commonly used replacement for colchicine in initial treatment of gout

Answer 22

Indomethacin

Question 23

Why is aspirin not used in gout?

Answer 23

Due to its renal retention of uric acid at low doses

Question 24

Uricosuric agent

Answer 24

Probenecid

Question 25

MOA of probenecid

Answer 25

Compete with uric acid for reabsorption in the proximal tubules

Question 26

MOA of allopurinol

Answer 26

Active metabolite irreversibly inhibits xanthine oxidase and lowers production of uric acid

Question 27

1st line treatment for chronic gout, tumor lysis syndrome

Answer 27

Allopurinol

Question 28

Inhibits metabolism of mercaptopurine and azathioprine

Answer 28

Allopurinol

Question 29

MOA of Febuxostat

Answer 29

Nonpurine reversible inhibitor of xanthine oxidase

Question 30

Inhibits microtubule assembly

Answer 30

Colchicine

Question 31

Commonly used replacement for colchicine in initial treatment of gout

Answer 31

Indomethacin

Question 32

Why is aspirin not used in gout?

Answer 32

Due to its renal retention of uric acid at low doses

Question 33

Uricosuric agent

Answer 33

Probenecid

Question 34

MOA of probenecid

Answer 34

Compete with uric acid for reabsorption in the proximal tubules

Question 35

MOA of allopurinol

Answer 35

Active metabolite irreversibly inhibits xanthine oxidase and lowers production of uric acid

Question 36

1st line treatment for chronic gout, tumor lysis syndrome

Answer 36

Allopurinol

Question 37

Inhibits metabolism of mercaptopurine and azathioprine

Answer 37

Allopurinol

Question 38

MOA of Febuxostat

Answer 38

Nonpurine reversible inhibitor of xanthine oxidase