Hyperlipidemia Flashcards
Drugs most effective at lowering LDL cholesterol
statins, resins, ezetimibe, niacin
Inhibits HMG-CoA Reductase
Statins
MOA of Simvastatin
reversible competitive inhibitor of HMG-CoA reductase
Drugs most effective at lowering TG and VLDL and raising HDL
niacin, rates
MOA of statins
reversible competitive inhibitor of HMG-CoA reductase
Why are statins used in CAD?
for stabilization of atherosclerotic plaques
MOA of Cholestyramine
binds bile acids
Bile-acid binding resins
Cholestyramine, Colesevelam, colestipol
SE of Resins
Constipation, Bloating, Gritty taste, malabsorption (vit K and folate)
MOA of Ezetimibe
selective inhibitor of NOC1L1 tansporter, decreasing intestinal absorption of cholesterol and other phytosterols
Cholesterol analog
Sitosterol - decrease interstinal absorption of cholesterol and other phytosterols
MOA of Niacin
decreases VLDL synthesis and LDL cholesterol concentrations, increases HDL cholesterol
SE of Niacin
Flushing, pruritus, rashes, acanthosis nigricans, etc…Pre-treat with Aspirin to reduce flushing
MOA of Gemfibrozil
Activates PPAR-alpha proteins and increases expression of lipoprotein lipase and apoA-I, apoA-II, lowers TGs, Increases HDL
Ligands for peroxisome proliferator-activated receptor alpha protein
Fibrates
