NSAIDs and Antigout Flashcards
NSAIDs
Large and chemically diverse group of drugs with analgesic, anti-inflammatory, and antipyretic properties
Aspirin has platelet inhibition properties
NSAIDs Contraindications
Known drug allergy
Aspirin allergy
Vitamin K deficiency
Peptic ulcer disease
NSAIDs Adverse Effects
GI bleeding
Acute renal failure
Increased risk of MI and stroke
Hepatotoxicity
NSAIDs and Renal Function
NSAIDs disrupt prostaglandins, which renal function is dependent on
NSAIDs Black Box Warning
Increased risk of adverse cardiovascular thrombotic events, including fatal MI and stroke
Not aspirin
Salicylates
Salicylic acid (aspirin)
Inhibits platelet aggregation
Reye’s syndrome in children who take aspirin
Prophylactic therapy for adults who have strong risk factors for developing coronary artery disease or cardiovascular accident
Aspirin Uses
Headache, neuralgia, myalgia, arthralgia
Arthritis, pleurisy, and pericarditis
Antipyretic action
Salicism
Increased heart rate
Tinnitus, hearing loss, dimness of vision, headache, dizziness
Nausea, vomiting, diarrhea
Sweating, thirst, hyperventilation, hypo/hyperglycemia
Indomethacin (Indocin)
EXTREMELY IRRITATING TO THE GI TRACT
Analgesic, antiinflammatory, antirheumatic, and antipyretic properties
Ketorolac (Toradol)
Short-term use only
Some antiinflammatory activity
Used for its powerful analgesic effects
Ibuprofen (Motrin, Advil)
Most commonly used NSAID
Naproxen (Aleve)
Second most commonly used NSAID
Fewer drug interactions with ACE inhibitors
Celecoxib (Celebrex)
COX-2 Inhibitor
Cardiovascular and GI issues
NSAIDs Adverse Effects
Dyspepsia, heartburn, epigastric distress, nausea
GI bleeding
Mucosal lesions
NSAIDs Interactions
Anticoagulants, aspirin, corticosteroids, protein-bound drugs, diuretics and ACE inhibitors
Gout
Condition that results from inappropriate uric acid metabolism
Uric acid crystals are deposited in tissues and joints, resulting in pain
Allopurinol (Zyloprim)
Used to prevent uric acid production and prevent acute tumor lysis syndrome
Colchicine
Reduces inflammatory response to the deposits of urate crystals in joint tissue
Used for short-term management or prevention of gout
May cause short-term leukopenia and bleeding into the GI or urinary tracts
