NSAIDS, Acetaminophen, DMARDS, anti-Gout

Question 0

NSAID contraindicated in gout

Answer 0

Aspirin

Question 1

Non-selective NSAIDs

Answer 1

Ibuprofen, indomethacin, ketorolac, piroxicam

Question 2

Aspirin dosage (mg/d): usage

Answer 2

<300: inhibit platelet aggregation
300-2400: antipyretic and analgesic
2400-4000: anti-inflammatory

Question 3

Only IV NSAID

restricted to 72hrs only

Answer 3

Ketorolac

Question 4

DOC for closure of PDA

Answer 4

Indomethacin

Question 5

Antidote for acetaminophen toxicity

Answer 5

N-acetylcysteine

Question 6

Hyperbilirubinemia (PCM toxicity)

Answer 6

Stage II: 24-72hrs

Question 7

Toxic dose/lethal dose

Answer 7

TD: 150mg/kg, 21 500 mg tab
LD: 15g, 30 500mg tab

Question 8

DMARDS

Answer 8

for connective tissue dse

6wks-6months before effective

Question 9

DMARDS

Answer 9

Methotrexate (leucovorin-rescue agent), DOC for RA:AICAR

Ifliximab: TNF-a
Azthioprine: 6-thioguanine, supress B-, T-cell
Chloroquine: supress T-lymph response
Cyclophosphamide: phosphoramide mustard
Cyclosporine: inhibits IL-1 and 2
Mycophenolate mofetil: inhibits IMP dehydrogenase
Sulfasalazine: inhibits cytokines

Question 10

Colchicine

Answer 10

Microtubule assembly inhibitor, decreases macrophage migration and phagocytosis

Question 11

Uricosuric agent

Answer 11

Probenecid, sulfinpyrazone

Inc uric acid excretion

Question 12

Xanthine oxidase inhibitor

Answer 12

Allopurinol

For chronic gout